Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat
Aquaporin-4 (AQP4) is a member of a water-selective channel aquaporin-family and mainly expressed in the several structures of the brain and in the collecting duct of the kidney. Here we show its functional involvement in the water homeostasis of the ischemic brain. The expression of AQP4–mRNA is in...
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| Veröffentlicht in: | Brain research. Molecular brain research. 2000-05, Vol.78 (1), p.131-137 |
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| container_title | Brain research. Molecular brain research. |
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| creator | Taniguchi, Masaaki Yamashita, Toshihide Kumura, Eiji Tamatani, Michio Kobayashi, Akihiro Yokawa, Takashi Maruno, Motohiko Kato, Amami Ohnishi, Takanori Kohmura, Eiji Tohyama, Masaya Yoshimine, Toshiki |
| description | Aquaporin-4 (AQP4) is a member of a water-selective channel aquaporin-family and mainly expressed in the several structures of the brain and in the collecting duct of the kidney. Here we show its functional involvement in the water homeostasis of the ischemic brain. The expression of AQP4–mRNA is increased in the peri-infarcted cortex during the observation period (∼7 days) after MCA-occlusion, maximally on day 3. The change corresponds to the generation and resolution of brain edema monitored by MRI. The signals for the mRNA are predominantly observed in glial cells in the molecular and outer granular layer of the peri-infarcted cortex. These results indicate that AQP4 plays a role in post-ischemic edema formation. |
| doi_str_mv | 10.1016/S0169-328X(00)00084-X |
| format | Article |
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Here we show its functional involvement in the water homeostasis of the ischemic brain. The expression of AQP4–mRNA is increased in the peri-infarcted cortex during the observation period (∼7 days) after MCA-occlusion, maximally on day 3. The change corresponds to the generation and resolution of brain edema monitored by MRI. The signals for the mRNA are predominantly observed in glial cells in the molecular and outer granular layer of the peri-infarcted cortex. 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Molecular brain research.</title><addtitle>Brain Res Mol Brain Res</addtitle><description>Aquaporin-4 (AQP4) is a member of a water-selective channel aquaporin-family and mainly expressed in the several structures of the brain and in the collecting duct of the kidney. Here we show its functional involvement in the water homeostasis of the ischemic brain. The expression of AQP4–mRNA is increased in the peri-infarcted cortex during the observation period (∼7 days) after MCA-occlusion, maximally on day 3. The change corresponds to the generation and resolution of brain edema monitored by MRI. The signals for the mRNA are predominantly observed in glial cells in the molecular and outer granular layer of the peri-infarcted cortex. These results indicate that AQP4 plays a role in post-ischemic edema formation.</description><subject>Animals</subject><subject>Aquaporin 4</subject><subject>Aquaporins - genetics</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Brain Chemistry - physiology</subject><subject>Brain edema</subject><subject>Brain Edema - physiopathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Gene Expression - physiology</subject><subject>In Situ Hybridization</subject><subject>Infarction, Middle Cerebral Artery - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle cerebral artery occlusion</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - analysis</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>water channels</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaLZpf0KLDqW0B7cayZalUwihH4HQhDaBvQlZHhEVW95IdkP-fbXZpektB43E8Mzo5SHkDbBPwEB-_lWKrgRX6w-MfWSMqbpaPyMrUC2vpK7hOVn9Qw7Jy5x_FwgUwAtyCExpaDRfkcuz2C9uDlOkk6f2drGbKYVY1fTOzpiou7Ex4kDHnz9OqPXblp-cHajDhF0qj5DdDY7B0hBpsvMrcuDtkPH1_j4i11-_XJ1-r84vvp2dnpxXrhF6rpyqGTopvNOat61X2kHvrbItV2ibumt4q6XATmklO5C9YgI1k6LWnDMEcUTe7_Zu0nS7YJ7NWJLgMNiI05JNC1wIofmTILRNU84WbHagS1POCb3ZpDDadG-Ama1z8-DcbIUaxsyDc7Muc2_3HyzdiP1_UzvJBXi3B2wu6nyy0YX8yNWyFSALdrzDsGj7EzCZ7AJGh31I6GbTT-GJJH8BZxqclA</recordid><startdate>20000531</startdate><enddate>20000531</enddate><creator>Taniguchi, Masaaki</creator><creator>Yamashita, Toshihide</creator><creator>Kumura, Eiji</creator><creator>Tamatani, Michio</creator><creator>Kobayashi, Akihiro</creator><creator>Yokawa, Takashi</creator><creator>Maruno, Motohiko</creator><creator>Kato, Amami</creator><creator>Ohnishi, Takanori</creator><creator>Kohmura, Eiji</creator><creator>Tohyama, Masaya</creator><creator>Yoshimine, Toshiki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000531</creationdate><title>Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat</title><author>Taniguchi, Masaaki ; Yamashita, Toshihide ; Kumura, Eiji ; Tamatani, Michio ; Kobayashi, Akihiro ; Yokawa, Takashi ; Maruno, Motohiko ; Kato, Amami ; Ohnishi, Takanori ; Kohmura, Eiji ; Tohyama, Masaya ; Yoshimine, Toshiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-c840ec63fc99277f89c1dfa8a728ea54b527963eb8986b16d803e906349220e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Aquaporin 4</topic><topic>Aquaporins - genetics</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Brain Chemistry - physiology</topic><topic>Brain edema</topic><topic>Brain Edema - physiopathology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Gene Expression - physiology</topic><topic>In Situ Hybridization</topic><topic>Infarction, Middle Cerebral Artery - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle cerebral artery occlusion</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - analysis</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>water channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taniguchi, Masaaki</creatorcontrib><creatorcontrib>Yamashita, Toshihide</creatorcontrib><creatorcontrib>Kumura, Eiji</creatorcontrib><creatorcontrib>Tamatani, Michio</creatorcontrib><creatorcontrib>Kobayashi, Akihiro</creatorcontrib><creatorcontrib>Yokawa, Takashi</creatorcontrib><creatorcontrib>Maruno, Motohiko</creatorcontrib><creatorcontrib>Kato, Amami</creatorcontrib><creatorcontrib>Ohnishi, Takanori</creatorcontrib><creatorcontrib>Kohmura, Eiji</creatorcontrib><creatorcontrib>Tohyama, Masaya</creatorcontrib><creatorcontrib>Yoshimine, Toshiki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. 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| subjects | Animals Aquaporin 4 Aquaporins - genetics Autoradiography Biological and medical sciences Blotting, Northern Brain Chemistry - physiology Brain edema Brain Edema - physiopathology Brain Ischemia - physiopathology Gene Expression - physiology In Situ Hybridization Infarction, Middle Cerebral Artery - physiopathology Male Medical sciences Middle cerebral artery occlusion Neurology Rats Rats, Wistar RNA, Messenger - analysis Vascular diseases and vascular malformations of the nervous system water channels |
| title | Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat |
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