Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum
The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate) 2, VO(picolinate) 2 and VO(6-Me-picolinate) 2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their te...
Gespeichert in:
| Veröffentlicht in: | Journal of inorganic biochemistry 2000-05, Vol.80 (1), p.65-73 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 73 |
|---|---|
| container_issue | 1 |
| container_start_page | 65 |
| container_title | Journal of inorganic biochemistry |
| container_volume | 80 |
| creator | Kiss, Tamás Kiss, Erzsébet Garribba, Eugenio Sakurai, Hiromu |
| description | The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)
2, VO(picolinate)
2 and VO(6-Me-picolinate)
2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account. |
| doi_str_mv | 10.1016/S0162-0134(00)00041-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71233330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0162013400000416</els_id><sourcerecordid>71233330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-1407410daadeed007791c63aa0750d4a3024bd740ecb507fbd1187031c97c0333</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqXwE0CZUDsEzrUTtxNC5atSpQ6FrpZjXyujJC52gsS_x20QYmO5W573Xt1DyCWFGwo0v13FMU6BMj4EGAEAp2l-RPp0IljKGOfHpP-L9MhZCO8RyjIuTkmPwmSS8Tzrk4fVDrVVjXV14jaJrUNb2jqtbIWN1cl6OZyvR6l2daNsbettYny7DZFLitI5kwT0bXVOTjaqDHjxswfk7enxdfaSLpbP89n9ItVcTJuUchCcglHKIBoAIaZU50wpEBkYrhiMeWEEB9RFBmJTGBq_AUb1VGhgjA3IdXd3591Hi6GRlQ0ay1LV6NogBR1HikEEsw7U3oXgcSN33lbKf0kKcq9PHvTJvRsJIA_6ZB5zVz8FbVGh-ZPqfEXgrgMwvvlp0cugLdYajfWoG2mc_afiG9X2fWI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71233330</pqid></control><display><type>article</type><title>Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kiss, Tamás ; Kiss, Erzsébet ; Garribba, Eugenio ; Sakurai, Hiromu</creator><creatorcontrib>Kiss, Tamás ; Kiss, Erzsébet ; Garribba, Eugenio ; Sakurai, Hiromu</creatorcontrib><description>The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)
2, VO(picolinate)
2 and VO(6-Me-picolinate)
2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/S0162-0134(00)00041-6</identifier><identifier>PMID: 10885465</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blood serum ; Citric Acid - chemistry ; Electron Spin Resonance Spectroscopy ; Hydrogen-Ion Concentration ; Insulin - pharmacology ; Insulin-mimetic VO(IV) ; Lactic Acid - chemistry ; Ligands ; Models, Molecular ; Molecular Structure ; Phosphates - chemistry ; Picolinic Acids - chemistry ; Serum Albumin - metabolism ; Transferrin - metabolism ; Vanadates - blood ; VO(IV)-containing drugs</subject><ispartof>Journal of inorganic biochemistry, 2000-05, Vol.80 (1), p.65-73</ispartof><rights>2000 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-1407410daadeed007791c63aa0750d4a3024bd740ecb507fbd1187031c97c0333</citedby><cites>FETCH-LOGICAL-c479t-1407410daadeed007791c63aa0750d4a3024bd740ecb507fbd1187031c97c0333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0162-0134(00)00041-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10885465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiss, Tamás</creatorcontrib><creatorcontrib>Kiss, Erzsébet</creatorcontrib><creatorcontrib>Garribba, Eugenio</creatorcontrib><creatorcontrib>Sakurai, Hiromu</creatorcontrib><title>Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)
2, VO(picolinate)
2 and VO(6-Me-picolinate)
2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account.</description><subject>Blood serum</subject><subject>Citric Acid - chemistry</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Hydrogen-Ion Concentration</subject><subject>Insulin - pharmacology</subject><subject>Insulin-mimetic VO(IV)</subject><subject>Lactic Acid - chemistry</subject><subject>Ligands</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Phosphates - chemistry</subject><subject>Picolinic Acids - chemistry</subject><subject>Serum Albumin - metabolism</subject><subject>Transferrin - metabolism</subject><subject>Vanadates - blood</subject><subject>VO(IV)-containing drugs</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwE0CZUDsEzrUTtxNC5atSpQ6FrpZjXyujJC52gsS_x20QYmO5W573Xt1DyCWFGwo0v13FMU6BMj4EGAEAp2l-RPp0IljKGOfHpP-L9MhZCO8RyjIuTkmPwmSS8Tzrk4fVDrVVjXV14jaJrUNb2jqtbIWN1cl6OZyvR6l2daNsbettYny7DZFLitI5kwT0bXVOTjaqDHjxswfk7enxdfaSLpbP89n9ItVcTJuUchCcglHKIBoAIaZU50wpEBkYrhiMeWEEB9RFBmJTGBq_AUb1VGhgjA3IdXd3591Hi6GRlQ0ay1LV6NogBR1HikEEsw7U3oXgcSN33lbKf0kKcq9PHvTJvRsJIA_6ZB5zVz8FbVGh-ZPqfEXgrgMwvvlp0cugLdYajfWoG2mc_afiG9X2fWI</recordid><startdate>20000530</startdate><enddate>20000530</enddate><creator>Kiss, Tamás</creator><creator>Kiss, Erzsébet</creator><creator>Garribba, Eugenio</creator><creator>Sakurai, Hiromu</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000530</creationdate><title>Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum</title><author>Kiss, Tamás ; Kiss, Erzsébet ; Garribba, Eugenio ; Sakurai, Hiromu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-1407410daadeed007791c63aa0750d4a3024bd740ecb507fbd1187031c97c0333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Blood serum</topic><topic>Citric Acid - chemistry</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Hydrogen-Ion Concentration</topic><topic>Insulin - pharmacology</topic><topic>Insulin-mimetic VO(IV)</topic><topic>Lactic Acid - chemistry</topic><topic>Ligands</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Phosphates - chemistry</topic><topic>Picolinic Acids - chemistry</topic><topic>Serum Albumin - metabolism</topic><topic>Transferrin - metabolism</topic><topic>Vanadates - blood</topic><topic>VO(IV)-containing drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiss, Tamás</creatorcontrib><creatorcontrib>Kiss, Erzsébet</creatorcontrib><creatorcontrib>Garribba, Eugenio</creatorcontrib><creatorcontrib>Sakurai, Hiromu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiss, Tamás</au><au>Kiss, Erzsébet</au><au>Garribba, Eugenio</au><au>Sakurai, Hiromu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2000-05-30</date><risdate>2000</risdate><volume>80</volume><issue>1</issue><spage>65</spage><epage>73</epage><pages>65-73</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)
2, VO(picolinate)
2 and VO(6-Me-picolinate)
2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10885465</pmid><doi>10.1016/S0162-0134(00)00041-6</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-0134 |
| ispartof | Journal of inorganic biochemistry, 2000-05, Vol.80 (1), p.65-73 |
| issn | 0162-0134 1873-3344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71233330 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Blood serum Citric Acid - chemistry Electron Spin Resonance Spectroscopy Hydrogen-Ion Concentration Insulin - pharmacology Insulin-mimetic VO(IV) Lactic Acid - chemistry Ligands Models, Molecular Molecular Structure Phosphates - chemistry Picolinic Acids - chemistry Serum Albumin - metabolism Transferrin - metabolism Vanadates - blood VO(IV)-containing drugs |
| title | Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T19%3A53%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Speciation%20of%20insulin-mimetic%20VO(IV)-containing%20drugs%20in%20blood%20serum&rft.jtitle=Journal%20of%20inorganic%20biochemistry&rft.au=Kiss,%20Tam%C3%A1s&rft.date=2000-05-30&rft.volume=80&rft.issue=1&rft.spage=65&rft.epage=73&rft.pages=65-73&rft.issn=0162-0134&rft.eissn=1873-3344&rft_id=info:doi/10.1016/S0162-0134(00)00041-6&rft_dat=%3Cproquest_cross%3E71233330%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71233330&rft_id=info:pmid/10885465&rft_els_id=S0162013400000416&rfr_iscdi=true |