E2A and EBF Act in Synergy with the V(D)J Recombinase to Generate a Diverse Immunoglobulin Repertoire in Nonlymphoid Cells

Immunoglobulin (Ig) and T cell receptor (TCR) genes are assembled during lymphocyte maturation through site-specific V(D)J recombination events. Here we show that E2A proteins act in concert with RAG1 and RAG2 to activate Ig Vκ1J but not Igλ VλIII–Jλ1 rearrangement in an embryonic kidney cell line....

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Veröffentlicht in:	Molecular cell 2000-02, Vol.5 (2), p.343-353
Hauptverfasser:	Romanow, William J, Langerak, Anton W, Goebel, Peter, Wolvers-Tettero, Ingrid L.M, van Dongen, Jacques J.M, Feeney, Ann J, Murre, Cornelis
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors DNA Nucleotidyltransferases - metabolism DNA-Binding Proteins - metabolism E2A protein EBF protein Gene Rearrangement Genes, Immunoglobulin Homeodomain Proteins - metabolism Immunoglobulin G - genetics Immunoglobulin Heavy Chains - genetics Immunoglobulin Joining Region - genetics Immunoglobulin kappa-Chains - genetics Immunoglobulin Variable Region - genetics Immunoglobulins - genetics Kidney - cytology Kidney - embryology Kidney - physiology NF-kappa B - metabolism Nuclear Proteins - metabolism PAX5 Transcription Factor Proto-Oncogene Proteins Recombination, Genetic Trans-Activators - metabolism Transcription Factors - metabolism Transcriptional Activation V(D)J recombinase VDJ Recombinases
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