Mitochondrion as a Novel Target of Anticancer Chemotherapy

Mitochondrial membrane permeabilization is a critical event in the process leading to physiologic or chemotherapy-induced apoptosis (programmed cell death). This permeabilization event is, at least in part, under the control of the permeability transition pore complex (PTPC). Oncoproteins from the B...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2000-07, Vol.92 (13), p.1042-1053
Hauptverfasser:	Costantini, Paola, Jacotot, Etienne, Decaudin, Didier, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Biological and medical sciences Cancer Cells Chemotherapy Humans Intracellular Membranes - drug effects Medical sciences Membranes Mitochondria - drug effects Mitochondria - metabolism Neoplasms - drug therapy Neoplasms - metabolism Permeability - drug effects Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction
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