Minor Thiols Cysteine and Cysteinylglycine Regulate the Competition between Glutathione and Protein SH Groups in Human Platelets Subjected to Oxidative Stress

Changes in the concentrations of protein-mixed disulfides (XS-SP) of glutathione (GSH), cysteine (CSH), and cysteinylglycine (CGSH) were studied in human platelets treated with diamide and t-BOOH in timecourse experiments (time range, 1–30 min) in order to understand the contribution of minor thiols...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2000-08, Vol.380 (1), p.1-10
Hauptverfasser:	Giustarini, Daniela, Campoccia, Giuseppe, Fanetti, Giuseppe, Rossi, Ranieri, Giannerini, Fabiola, Lusini, Lorenzo, Di Simplicio, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant enzymes Antioxidants - metabolism Blood Platelets - drug effects Blood Platelets - metabolism Chromatography, High Pressure Liquid cysteine Cysteine - metabolism cysteinylglycine Diamide - pharmacology Dipeptides - metabolism Disulfides - metabolism Dithionitrobenzoic Acid - pharmacology Erythrocytes - metabolism glutathione Glutathione - metabolism human platelets Humans Oxidative Stress protein SH groups S-thiolation/dethiolation Spectrophotometry src Homology Domains Sulfhydryl Compounds - physiology tert-Butylhydroperoxide - pharmacology Time Factors
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