Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease

Trehalose is a disaccharide, the main dietary source being mushrooms. It has been approved as an additive in the preparation of dried food. Isolated intestinal trehalase deficiency is found in 8 % of Greenlanders, but is rare elsewhere. The normal range of trehalase activity and the incidence of iso...

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Veröffentlicht in:British journal of nutrition 2000-03, Vol.83 (3), p.241-245
Hauptverfasser: Murray, Iain A., Coupland, Kathryn, Smith, Julie A., Ansell, I. David, Long, Richard G.
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container_issue 3
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container_title British journal of nutrition
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creator Murray, Iain A.
Coupland, Kathryn
Smith, Julie A.
Ansell, I. David
Long, Richard G.
description Trehalose is a disaccharide, the main dietary source being mushrooms. It has been approved as an additive in the preparation of dried food. Isolated intestinal trehalase deficiency is found in 8 % of Greenlanders, but is rare elsewhere. The normal range of trehalase activity and the incidence of isolated trehalase deficiency in the UK have not been reported. Patients (n 400) were investigated for suspected malabsorption. Endoscopic distal duodenal biopsies were taken for histological assessment and maltase, sucrase, lactase and trehalase estimation. Disaccharidase activities were determined by Dahlqvist's technique (). Most patients (n 369) had normal duodenal histology. In these, square root transformation of trehalase activity produced a normal distribution. The normal range (mean ± 2 SD) was 4·79–37·12 U/g protein. One patient had an isolated borderline trehalase deficiency. The thirty-one patients with villous atrophy had significantly reduced disaccharidase activities. With ingestion of a gluten-free diet, maltase, sucrase and trehalase activities recovered to normal in most patients, whereas lactase activity did not. The normal range and very low incidence of isolated enzyme deficiency is comparable with that described in populations from the USA and mainland Europe. Activity is significantly reduced in untreated coeliac disease and recovers with treatment with a gluten-free diet. There is no place for routine determination of trehalase activity in the UK population and there should be no concern over the introduction of trehalose-containing dried foods.
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subjects Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Celiac Disease - enzymology
Coeliac disease
Disaccharidase
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Malabsorption Syndromes - enzymology
Malabsorption Syndromes - epidemiology
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Reference Values
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Trehalase - deficiency
Trehalase - metabolism
United Kingdom - epidemiology
title Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease
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