The Concentration-Effect Relationship of the Respiratory Depressant Effects of Alfentanil and Fentanyl

The relative potencies of fentanyl and alfentanil for respiratory depression were determined in eight healthy male volunteers in a double-blinded, randomized study with a cross-over design. The drugs were delivered by computer-driven infusion with logarithmically ascending plasma concentrations unti...

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Veröffentlicht in:	Anesthesia and analgesia 2001-10, Vol.93 (4), p.939-946
Hauptverfasser:	Mildh, Leena H., Scheinin, Harry, Kirvelä, Olli A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alfentanil - pharmacology Algorithms Analgesics, Opioid - pharmacology Biological and medical sciences Blood Pressure - drug effects Calorimetry, Indirect Cross-Over Studies Depression, Chemical Dose-Response Relationship, Drug Double-Blind Method Drug toxicity and drugs side effects treatment Electroencephalography - drug effects Fentanyl - pharmacology Humans Male Medical sciences Pharmacology. Drug treatments Plethysmography Respiratory Mechanics - drug effects Toxicity: respiratory system, ent, stomatology
Online-Zugang:	Volltext
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