The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms
Gastroesophageal reflux is a potential trigger of asthma that may be clinically silent. This study examines the prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. This prospective cohort study evaluated 26 patients with stable asthma without reflux symptoms using esoph...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2000-07, Vol.162 (1), p.34-39 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | HARDING, S. M GUZZO, M. R RICHTER, J. E |
| description | Gastroesophageal reflux is a potential trigger of asthma that may be clinically silent. This study examines the prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. This prospective cohort study evaluated 26 patients with stable asthma without reflux symptoms using esophageal manometry and 24-h esophageal pH testing. Gastroesophageal reflux was considered present if esophageal acid contact times were abnormal. Demographic variables were analyzed to determine if they predicted the presence of gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux were compared with 30 age-matched asthma patients with symptomatic gastroesophageal reflux. The prevalence of abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms was 62% (16 of 26). Demographic variables did not predict abnormal 24-h esophageal pH tests in asthma patients with asymptomatic gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux had higher amounts of proximal esophageal acid exposure (p < 0.05) compared with asthma patients with symptomatic gastroesophageal reflux. Because demographic variables do not predict abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms, 24-h esophageal pH testing is required. This study suggests that gastroesophageal reflux is present in asthma patients, even in the absence of esophageal symptoms. |
| doi_str_mv | 10.1164/ajrccm.162.1.9907072 |
| format | Article |
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Demographic variables did not predict abnormal 24-h esophageal pH tests in asthma patients with asymptomatic gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux had higher amounts of proximal esophageal acid exposure (p < 0.05) compared with asthma patients with symptomatic gastroesophageal reflux. Because demographic variables do not predict abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms, 24-h esophageal pH testing is required. This study suggests that gastroesophageal reflux is present in asthma patients, even in the absence of esophageal symptoms.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/ajrccm.162.1.9907072</identifier><identifier>PMID: 10903216</identifier><language>eng</language><publisher>New York, NY: American Lung Association</publisher><subject>Adult ; Asthma - complications ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Esophagus - metabolism ; Female ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - etiology ; Humans ; Hydrogen-Ion Concentration ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Prevalence ; Prospective Studies ; Severity of Illness Index</subject><ispartof>American journal of respiratory and critical care medicine, 2000-07, Vol.162 (1), p.34-39</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-35269ae795022997087e413a8d8acca172c638aae85cebb3138cd99a2024d4483</citedby><cites>FETCH-LOGICAL-c398t-35269ae795022997087e413a8d8acca172c638aae85cebb3138cd99a2024d4483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4025,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1439586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10903216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARDING, S. M</creatorcontrib><creatorcontrib>GUZZO, M. R</creatorcontrib><creatorcontrib>RICHTER, J. E</creatorcontrib><title>The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Gastroesophageal reflux is a potential trigger of asthma that may be clinically silent. This study examines the prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. This prospective cohort study evaluated 26 patients with stable asthma without reflux symptoms using esophageal manometry and 24-h esophageal pH testing. Gastroesophageal reflux was considered present if esophageal acid contact times were abnormal. Demographic variables were analyzed to determine if they predicted the presence of gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux were compared with 30 age-matched asthma patients with symptomatic gastroesophageal reflux. The prevalence of abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms was 62% (16 of 26). Demographic variables did not predict abnormal 24-h esophageal pH tests in asthma patients with asymptomatic gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux had higher amounts of proximal esophageal acid exposure (p < 0.05) compared with asthma patients with symptomatic gastroesophageal reflux. Because demographic variables do not predict abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms, 24-h esophageal pH testing is required. This study suggests that gastroesophageal reflux is present in asthma patients, even in the absence of esophageal symptoms.</description><subject>Adult</subject><subject>Asthma - complications</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Esophagus - metabolism</subject><subject>Female</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - etiology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1Lw0AQhhdRbK3-A5EcxFvifiXZPUrxCwpeKnhbpptJm5IvdxO1_95IInqagXnel-Eh5JLRiLFE3sLeWVtFLOERi7SmKU35EZmzWMSh1Ck9HnaailBK_TYjZ97vKWVcMXpKZoxqKjhL5mS93mHQOvyAEmuLQZMHW_Cda9A37Q62CGXgMC_7r6Cog-GyqyBooSuw7nzwWXS7pu9-CX-o2q6p_Dk5yaH0eDHNBXl9uF8vn8LVy-Pz8m4VWqFVF4qYJxow1THlXA8vqxQlE6AyBdYCS7lNhAJAFVvcbAQTymZaA6dcZlIqsSA3Y2_rmvcefWeqwlssS6ix6b1JGRdUcT2AcgSta7wfvjWtKypwB8Oo-bFpRptmsGmYmWwOsaupv99UmP0LjfoG4HoCwFsocwe1LfwfJ4WOVSK-AcZYf7k</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>HARDING, S. M</creator><creator>GUZZO, M. R</creator><creator>RICHTER, J. E</creator><general>American Lung Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms</title><author>HARDING, S. M ; GUZZO, M. R ; RICHTER, J. 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M</creatorcontrib><creatorcontrib>GUZZO, M. R</creatorcontrib><creatorcontrib>RICHTER, J. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARDING, S. M</au><au>GUZZO, M. R</au><au>RICHTER, J. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>162</volume><issue>1</issue><spage>34</spage><epage>39</epage><pages>34-39</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Gastroesophageal reflux is a potential trigger of asthma that may be clinically silent. This study examines the prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. This prospective cohort study evaluated 26 patients with stable asthma without reflux symptoms using esophageal manometry and 24-h esophageal pH testing. Gastroesophageal reflux was considered present if esophageal acid contact times were abnormal. Demographic variables were analyzed to determine if they predicted the presence of gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux were compared with 30 age-matched asthma patients with symptomatic gastroesophageal reflux. The prevalence of abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms was 62% (16 of 26). Demographic variables did not predict abnormal 24-h esophageal pH tests in asthma patients with asymptomatic gastroesophageal reflux. Asthma patients with asymptomatic gastroesophageal reflux had higher amounts of proximal esophageal acid exposure (p < 0.05) compared with asthma patients with symptomatic gastroesophageal reflux. Because demographic variables do not predict abnormal 24-h esophageal pH tests in asthma patients without reflux symptoms, 24-h esophageal pH testing is required. This study suggests that gastroesophageal reflux is present in asthma patients, even in the absence of esophageal symptoms.</abstract><cop>New York, NY</cop><pub>American Lung Association</pub><pmid>10903216</pmid><doi>10.1164/ajrccm.162.1.9907072</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 2000-07, Vol.162 (1), p.34-39 |
| issn | 1073-449X 1535-4970 |
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| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Asthma - complications Biological and medical sciences Chronic obstructive pulmonary disease, asthma Esophagus - metabolism Female Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - etiology Humans Hydrogen-Ion Concentration Male Medical sciences Middle Aged Pneumology Prevalence Prospective Studies Severity of Illness Index |
| title | The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms |
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