A Potent Aldose Reductase Inhibitor, (2S,4S)-6-Fluoro-2‘,5‘-dioxospiro[chroman-4,4‘-imidazolidine]-2-carboxamide (Fidarestat):  Its Absolute Configuration and Interactions with the Aldose Reductase by X-ray Crystallography

The absolute configuration of the aldose reductase (AR) inhibitor, (+)-(2S,4S)-6-fluoro-2‘,5‘-dioxospiro[chroman-4,4‘-imidazolidine]-2-carboxamide (fidarestat), was established indirectly by single-crystal X-ray analysis of (+)-(2S,4S)-8-bromo-6-fluoro-2‘,5‘-dioxospiro[chroman-4,4‘-imidazolidine]-2-...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-06, Vol.43 (12), p.2479-2483
Hauptverfasser:	Oka, Mitsuru, Matsumoto, Yukiharu, Sugiyama, Shigeru, Tsuruta, Nobuaki, Matsushima, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Aldehyde Reductase - chemistry Binding Sites Biological and medical sciences Crystallography, X-Ray Enzyme Inhibitors - chemistry General and cellular metabolism. Vitamins Humans Imidazoles - chemistry Imidazolidines Medical sciences Models, Molecular Molecular Structure Pharmacology. Drug treatments Stereoisomerism
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