Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition

The membrane-bound sterol methyl transferase (SMT) enzyme from Prototheca wickerhamii, a non-photosynthetic, yeast-like alga, was found to C-methylate appropriate delta24(25)-sterol acceptor molecules to delta25(27)-24beta-methyl products stereoselectively. Incubation with pairs of substrates--[2H3-...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2000-05, Vol.8 (5), p.925-936
Hauptverfasser:	MANGLA, A. T, NES, W. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Methyltransferases - antagonists & inhibitors Methyltransferases - chemistry Methyltransferases - isolation & purification Methyltransferases - metabolism Prototheca - enzymology Sterols - chemistry Sterols - metabolism Structure-Activity Relationship Transferases
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