A “Traceless” Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds

Here we report a novel modification of our previously reported “Staudinger ligation” that generates an amide bond from an azide and a specifically functionalized phosphine. This method for the selective formation of an amide bond, which does not require the orthogonal protection of distal functional...

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Veröffentlicht in:	Organic letters 2000-07, Vol.2 (14), p.2141-2143
Hauptverfasser:	Saxon, Eliana, Armstrong, Joshua I, Bertozzi, Carolyn R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Chromatography, High Pressure Liquid Indicators and Reagents Molecular Conformation
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description	Here we report a novel modification of our previously reported “Staudinger ligation” that generates an amide bond from an azide and a specifically functionalized phosphine. This method for the selective formation of an amide bond, which does not require the orthogonal protection of distal functional groups, should find general utility in synthetic and biological chemistry.
doi_str_mv	10.1021/ol006054v
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subjects	Amides - chemical synthesis Amides - chemistry Chromatography, High Pressure Liquid Indicators and Reagents Molecular Conformation
title	A “Traceless” Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds
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