A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo

Urokinase plasminogen activator (uPA) plays an important role in the progression of several malignancies including breast cancer. We have identified a noncompetitive antagonist of the uPA‐uPAR interaction derived from a nonreceptor binding region of uPA (amino acids 136‐143). This 8‐mer capped pepti...

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Veröffentlicht in:	The FASEB journal 2000-07, Vol.14 (10), p.1400-1410
Hauptverfasser:	Guo, Yongjing, Higazi, Abd Al‐Roof, Arakelian, Ani, Sachais, Bruce S., Cines, Douglas, Goldfarb, Ronald H., Jones, Terence R., Kwaan, H., Mazar, Andrew P., Rabbani, Shafaat A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals apoptosis breast cancer Breast Neoplasms - blood supply Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Death - drug effects Cell Movement - drug effects endothelial cell Female Humans Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Necrosis Neoplasm Metastasis - prevention & control Neovascularization, Pathologic - prevention & control Peptide Fragments - chemistry Peptide Fragments - pharmacology Rats Rats, Inbred F344 Receptors, Cell Surface - metabolism Receptors, Urokinase Plasminogen Activator Tumor Cells, Cultured tumor necrosis Urokinase-Type Plasminogen Activator - chemistry Urokinase-Type Plasminogen Activator - metabolism Urokinase-Type Plasminogen Activator - pharmacology
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