β-Cell dysfunction in 48-hour glucose-infused rats is not a consequence of elevated plasma lipid or islet triglyceride levels

The abnormal insulin secretion found in human diabetics and animal models of diabetes has been attributed to the deleterious effects of chronic hyperglycemia and/or elevated circulating levels of nonesterified fatty acids (NEFAs). In this study, abnormal glucose-induced insulin secretion (GIIS) was...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2000-06, Vol.49 (6), p.755-759
Hauptverfasser:	de Souza, Christopher J., Capotorto, John V., Cornell-Kennon, Susan, Wu, Ying-Jian, Steil, Gary M., Trivedi, Nitin, Weir, Gordon C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - metabolism Cholesterol - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - blood Glucose - administration & dosage Glucose - pharmacology Hyperglycemia - blood Hyperglycemia - metabolism Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Islets of Langerhans - pathology Lipids - blood Male Medical sciences Rats Rats, Sprague-Dawley Triglycerides - analysis
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