Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis

Thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) is an enzyme involved in thymidine metabolism and homeostasis, and its catalytic activity appears to play an important role in angiogenesis. Here we describe the cloning and expression of a His-tagged human TP/PD-EC...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-06, Vol.43 (13), p.2601-2607
Hauptverfasser:	Focher, Federico, Ubiali, Daniela, Pregnolato, Massimo, Zhi, Chengxin, Gambino, Joseph, Wright, George E, Spadari, Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Biological and medical sciences Blood Platelets - chemistry Cloning, Molecular Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry General aspects Humans Medical sciences Molecular Sequence Data Neoplasms - blood supply Neovascularization, Pathologic - drug therapy Pharmacology. Drug treatments Structure-Activity Relationship Thymidine Phosphorylase - antagonists & inhibitors Thymidine Phosphorylase - isolation & purification Thymidine Phosphorylase - metabolism Uracil - analogs & derivatives Uracil - chemical synthesis Uracil - chemistry
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