In Situ Photoaffinity Labeling of Proteasome with Photoactive Adriamycin Analogue

An intracellular adriamycin (ADM)-binding protein purified from the cytosol of L1210 mouse lymphocytic leukemia cells had a molecular weight of 700–1500 kDa and hydrolyzed Suc-LLVY-MCA. When L1210 cells were incubated with a photoactive ADM analogue, N-(p-azidobenzoyl)-adriamycin (NAB-ADM), most of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-07, Vol.273 (3), p.928-932
Hauptverfasser:	Kiyomiya, Ken-ichi, Matsuo, Saburou, Kurebe, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	adriamycin Animals cancer cell Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - isolation & purification Doxorubicin - analogs & derivatives Doxorubicin - chemistry Electrophoresis, Polyacrylamide Gel Leukemia L1210 - pathology Mice Multienzyme Complexes - chemistry Multienzyme Complexes - isolation & purification nuclear transport photoaffinity labeling Photoaffinity Labels proteasome Proteasome Endopeptidase Complex Tumor Cells, Cultured
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