Conjugation with (111)In-DTPA-poly(ethylene glycol) improves imaging of anti-EGF receptor antibody C225

Significant liver uptake often limits the clinical application of radiolabeled antibodies in radioimmunodetection. The purpose of this study was to evaluate the gamma-imaging properties of an antiepidermal growth factor receptor (EGFR) antibody, C225, conjugated with heterofunctional poly(ethylene g...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2001-10, Vol.42 (10), p.1530-1537
Hauptverfasser:	Wen, X, Wu, Q P, Ke, S, Ellis, L, Charnsangavej, C, Delpassand, A S, Wallace, S, Li, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal, Humanized Cetuximab Female Humans Immunoconjugates Indium Radioisotopes - pharmacokinetics Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - diagnostic imaging Pentetic Acid - pharmacokinetics Polyethylene Glycols - pharmacokinetics Radionuclide Imaging Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Tissue Distribution Tumor Cells, Cultured - metabolism
Online-Zugang:	Volltext
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