Induction of the Soybean Phytoalexins Coumestrol and Glyceollin by Aspergillus
Several isoflavonoid phytoalexins produced by soybeans are known to be estrogenic, with potential beneficial health effects in humans. Increased production of phytoalexins by the soybean plant will facilitate research efforts in this area. In this study, phytoalexin induction and accumulation in soy...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2000-06, Vol.48 (6), p.2167-2172 |
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| creator | Boué, Stephen M Carter, Carol H Ehrlich, Kenneth C Cleveland, Thomas E |
| description | Several isoflavonoid phytoalexins produced by soybeans are known to be estrogenic, with potential beneficial health effects in humans. Increased production of phytoalexins by the soybean plant will facilitate research efforts in this area. In this study, phytoalexin induction and accumulation in soybean cotyledon tissue was observed using four species of Aspergillus: A. sojae, A. oryzae, A. niger, and A. flavus. All four Aspergillus species tested elicited phytoalexin accumulation in living soybean cotyledons. Results from a time course study indicated that maximum concentrations of the phytoalexin glyceollin, 955 μg/g fresh weight (fw), occurred at day 3 in soybean cotyledon tissue inoculated with A. sojae. Other Aspergillus species caused an accumulation of glyceollin at significantly lower levels. A maximum concentration of coumestrol of 27.2 μg/g fw was obtained from soybean cotyledons inoculated with A. niger. Soybean phytoalexins induced by food-grade A. sojae and A. oryzae allowed the collection of higher concentrations of phytoalexins for further examination in several in vitro and in vivo biological studies conducted to determine potential estrogenic activities. Keywords: Phytoalexin; isoflavone; glyceollin; coumestrol; Aspergillus; A. sojae; A. oryzae; A.niger; A. flavus; phytoestrogen |
| doi_str_mv | 10.1021/jf9912809 |
| format | Article |
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Increased production of phytoalexins by the soybean plant will facilitate research efforts in this area. In this study, phytoalexin induction and accumulation in soybean cotyledon tissue was observed using four species of Aspergillus: A. sojae, A. oryzae, A. niger, and A. flavus. All four Aspergillus species tested elicited phytoalexin accumulation in living soybean cotyledons. Results from a time course study indicated that maximum concentrations of the phytoalexin glyceollin, 955 μg/g fresh weight (fw), occurred at day 3 in soybean cotyledon tissue inoculated with A. sojae. Other Aspergillus species caused an accumulation of glyceollin at significantly lower levels. A maximum concentration of coumestrol of 27.2 μg/g fw was obtained from soybean cotyledons inoculated with A. niger. Soybean phytoalexins induced by food-grade A. sojae and A. oryzae allowed the collection of higher concentrations of phytoalexins for further examination in several in vitro and in vivo biological studies conducted to determine potential estrogenic activities. Keywords: Phytoalexin; isoflavone; glyceollin; coumestrol; Aspergillus; A. sojae; A. oryzae; A.niger; A. flavus; phytoestrogen</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf9912809</identifier><identifier>PMID: 10888516</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Aspergillus - metabolism ; Aspergillus flavus - metabolism ; Aspergillus niger - metabolism ; Aspergillus oryzae - metabolism ; Benzopyrans - metabolism ; Biological and medical sciences ; Biotechnology ; Cotyledon - metabolism ; Coumestrol - biosynthesis ; Food industries ; Food microbiology ; Fundamental and applied biological sciences. Psychology ; Glycine max - metabolism ; Glycine max - microbiology ; Health. Pharmaceutical industry ; Humans ; Industrial applications and implications. Economical aspects ; Other active biomolecules ; Production of active biomolecules ; Pterocarpans</subject><ispartof>Journal of agricultural and food chemistry, 2000-06, Vol.48 (6), p.2167-2172</ispartof><rights>Copyright © 2000 American Chemical Society</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a444t-2410a388230dadd9941c9831778dad5e3f2d7302581b7771b7ad26ab2c3501d3</citedby><cites>FETCH-LOGICAL-a444t-2410a388230dadd9941c9831778dad5e3f2d7302581b7771b7ad26ab2c3501d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf9912809$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf9912809$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1433738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10888516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boué, Stephen M</creatorcontrib><creatorcontrib>Carter, Carol H</creatorcontrib><creatorcontrib>Ehrlich, Kenneth C</creatorcontrib><creatorcontrib>Cleveland, Thomas E</creatorcontrib><title>Induction of the Soybean Phytoalexins Coumestrol and Glyceollin by Aspergillus</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Several isoflavonoid phytoalexins produced by soybeans are known to be estrogenic, with potential beneficial health effects in humans. Increased production of phytoalexins by the soybean plant will facilitate research efforts in this area. In this study, phytoalexin induction and accumulation in soybean cotyledon tissue was observed using four species of Aspergillus: A. sojae, A. oryzae, A. niger, and A. flavus. All four Aspergillus species tested elicited phytoalexin accumulation in living soybean cotyledons. Results from a time course study indicated that maximum concentrations of the phytoalexin glyceollin, 955 μg/g fresh weight (fw), occurred at day 3 in soybean cotyledon tissue inoculated with A. sojae. Other Aspergillus species caused an accumulation of glyceollin at significantly lower levels. A maximum concentration of coumestrol of 27.2 μg/g fw was obtained from soybean cotyledons inoculated with A. niger. Soybean phytoalexins induced by food-grade A. sojae and A. oryzae allowed the collection of higher concentrations of phytoalexins for further examination in several in vitro and in vivo biological studies conducted to determine potential estrogenic activities. Keywords: Phytoalexin; isoflavone; glyceollin; coumestrol; Aspergillus; A. sojae; A. oryzae; A.niger; A. flavus; phytoestrogen</description><subject>Aspergillus - metabolism</subject><subject>Aspergillus flavus - metabolism</subject><subject>Aspergillus niger - metabolism</subject><subject>Aspergillus oryzae - metabolism</subject><subject>Benzopyrans - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cotyledon - metabolism</subject><subject>Coumestrol - biosynthesis</subject><subject>Food industries</subject><subject>Food microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine max - metabolism</subject><subject>Glycine max - microbiology</subject><subject>Health. Pharmaceutical industry</subject><subject>Humans</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Other active biomolecules</subject><subject>Production of active biomolecules</subject><subject>Pterocarpans</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0FFrFDEQB_AgFnutPvgFJA8q-LCaSTaX7GM57bXQ1kIPfAzZJGv3zCXXZBe6376RPaoPfZlhmB_D8EfoPZCvQCh823ZNA1SS5hVaAKek4gDyNVqQsqwkX8IxOsl5SwiRXJA36BiIlJLDcoFuLoMdzdDHgGOHh3uH7-LUOh3w7f00RO3dYx8yXsVx5_KQosc6WLz2k3HR-z7gdsJnee_S7977Mb9FR5322b079FO0Of-xWV1UVz_Xl6uzq0rXdT1UtAaimZSUEautbZoaTCMZCCHLzB3rqBWMUC6hFUKUoi1d6pYaxglYdoo-z2f3KT6M5TG167Nx3uvg4piVAEoJr-sCv8zQpJhzcp3ap36n06SAqL_Zqefsiv1wODq2O2f_k3NYBXw8AJ2N9l3SwfT5n6sZE0wWVs2sz4N7fF7r9EctBRNcbW7vlLy5_r66-LVR6-I_zV6brLZxTKEk98J_T4QkkEI</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Boué, Stephen M</creator><creator>Carter, Carol H</creator><creator>Ehrlich, Kenneth C</creator><creator>Cleveland, Thomas E</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Induction of the Soybean Phytoalexins Coumestrol and Glyceollin by Aspergillus</title><author>Boué, Stephen M ; Carter, Carol H ; Ehrlich, Kenneth C ; Cleveland, Thomas E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a444t-2410a388230dadd9941c9831778dad5e3f2d7302581b7771b7ad26ab2c3501d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aspergillus - metabolism</topic><topic>Aspergillus flavus - metabolism</topic><topic>Aspergillus niger - metabolism</topic><topic>Aspergillus oryzae - metabolism</topic><topic>Benzopyrans - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cotyledon - metabolism</topic><topic>Coumestrol - biosynthesis</topic><topic>Food industries</topic><topic>Food microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine max - metabolism</topic><topic>Glycine max - microbiology</topic><topic>Health. Pharmaceutical industry</topic><topic>Humans</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Other active biomolecules</topic><topic>Production of active biomolecules</topic><topic>Pterocarpans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boué, Stephen M</creatorcontrib><creatorcontrib>Carter, Carol H</creatorcontrib><creatorcontrib>Ehrlich, Kenneth C</creatorcontrib><creatorcontrib>Cleveland, Thomas E</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boué, Stephen M</au><au>Carter, Carol H</au><au>Ehrlich, Kenneth C</au><au>Cleveland, Thomas E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of the Soybean Phytoalexins Coumestrol and Glyceollin by Aspergillus</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>48</volume><issue>6</issue><spage>2167</spage><epage>2172</epage><pages>2167-2172</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Several isoflavonoid phytoalexins produced by soybeans are known to be estrogenic, with potential beneficial health effects in humans. Increased production of phytoalexins by the soybean plant will facilitate research efforts in this area. In this study, phytoalexin induction and accumulation in soybean cotyledon tissue was observed using four species of Aspergillus: A. sojae, A. oryzae, A. niger, and A. flavus. All four Aspergillus species tested elicited phytoalexin accumulation in living soybean cotyledons. Results from a time course study indicated that maximum concentrations of the phytoalexin glyceollin, 955 μg/g fresh weight (fw), occurred at day 3 in soybean cotyledon tissue inoculated with A. sojae. Other Aspergillus species caused an accumulation of glyceollin at significantly lower levels. A maximum concentration of coumestrol of 27.2 μg/g fw was obtained from soybean cotyledons inoculated with A. niger. Soybean phytoalexins induced by food-grade A. sojae and A. oryzae allowed the collection of higher concentrations of phytoalexins for further examination in several in vitro and in vivo biological studies conducted to determine potential estrogenic activities. Keywords: Phytoalexin; isoflavone; glyceollin; coumestrol; Aspergillus; A. sojae; A. oryzae; A.niger; A. flavus; phytoestrogen</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>10888516</pmid><doi>10.1021/jf9912809</doi><tpages>6</tpages></addata></record> |
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| subjects | Aspergillus - metabolism Aspergillus flavus - metabolism Aspergillus niger - metabolism Aspergillus oryzae - metabolism Benzopyrans - metabolism Biological and medical sciences Biotechnology Cotyledon - metabolism Coumestrol - biosynthesis Food industries Food microbiology Fundamental and applied biological sciences. Psychology Glycine max - metabolism Glycine max - microbiology Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Other active biomolecules Production of active biomolecules Pterocarpans |
| title | Induction of the Soybean Phytoalexins Coumestrol and Glyceollin by Aspergillus |
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