Crystal structure of Urtica dioica agglutinin, a superantigen presented by MHC molecules of class I and class II

Background: Urtica dioica agglutinin (UDA), a monomeric lectin extracted from stinging nettle rhizomes, is specific for saccharides containing N-acetylglucosamine (GlcNAc). The lectin behaves as a superantigen for murine T cells, inducing the exclusive proliferation of Vβ8.3 + lymphocytes. UDA is un...

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Veröffentlicht in:	Structure (London) 2000-06, Vol.8 (6), p.593-603
Hauptverfasser:	Saul, Frederick A, Rovira, Paula, Boulot, Ginette, Van Damme, Els JM, Peumans, Willy J, Truffa-Bachi, Paolo, Bentley, Graham A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigen Presentation Binding Sites Carbohydrate Conformation Crystal structure Crystallography, X-Ray Histocompatibility Antigens Class I - metabolism Histocompatibility Antigens Class II - metabolism In Vitro Techniques Lectin Lectins - chemistry Lectins - genetics Lectins - metabolism Ligands Lymphocyte Activation Magnoliopsida - chemistry Magnoliopsida - genetics Magnoliopsida - immunology Mice Models, Molecular Molecular Sequence Data Plant Lectins Protein Conformation Receptors, Antigen, T-Cell, alpha-beta - metabolism Saccharide complex Sequence Homology, Amino Acid Superantigens - chemistry Superantigens - genetics Superantigens - metabolism T cell superantigen T-Lymphocytes - immunology Urtica dioica agglutinin
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