Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors

Background: Chemical inhibitors of cyclin-dependent kinases (CDKs) have great therapeutic potential against various proliferative and neurodegenerative disorders. Olomoucine, a 2,6,9-trisubstituted purine, has been optimized for activity against CDK1/cyclin B by combinatorial and medicinal chemistry...

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Veröffentlicht in:	Chemistry & biology 2000-06, Vol.7 (6), p.411-422
Hauptverfasser:	Knockaert, M, Gray, N, Damiens, E, Chang, Y-T, Grellier, P, Grant, K, Fergusson, D, Mottram, J, Soete, M, Dubremetz, J-F, Le Roch, K, Doerig, C, Schultz, PG, Meijer, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Casein kinase 1 Chromatography, Affinity - methods Cyclin-dependent kinases Cyclin-Dependent Kinases - antagonists & inhibitors Enzyme Inhibitors - pharmacology Erk Eukaryota - enzymology Malaria Molecular Sequence Data Oocytes - drug effects Oocytes - enzymology Purine Rats Starfish - cytology Substrate Specificity Swine Xenopus laevis
Online-Zugang:	Volltext
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