The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer

The type I receptor tyrosine kinases constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been implicated in the initiation and progression of several types of human malignancies. The best characterized of these proteins are the epidermal gro...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-10, Vol.61 (19), p.7196-7203
Hauptverfasser:	RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cell Division - drug effects Chemotherapy Drug Screening Assays, Antitumor Enzyme Inhibitors - pharmacology Female Growth Inhibitors - pharmacology Humans Medical sciences Mice Mice, SCID Pharmacology. Drug treatments Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, ErbB-2 - antagonists & inhibitors Structure-Activity Relationship Tumor Cells, Cultured Xenograft Model Antitumor Assays
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