An endogenous pentapeptide acting as a sodium channel blocker in inflammatory autoimmune disorders of the central nervous system

Reversible blockade of sodium channels by endogenous substances has been claimed to account for the fast exacerbations and relapses commonly seen in demyelinating autoimmune diseases 2 , 3 , 4 . Evidence has been provided that in the cerebrospinal fluid of patients with multiple sclerosis 5 or Guill...

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Veröffentlicht in:	Nature medicine 2000-07, Vol.6 (7), p.808-811
Hauptverfasser:	Brinkmeier, Heinrich, Aulkemeyer, Peter, Wollinsky, Kurt H., Rüdel, Reinhardt
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Biomedical and Life Sciences Biomedicine Cancer Research Central nervous system Cerebrospinal fluid Cerebrospinal Fluid - chemistry Chromatography Guillain-Barre Syndrome - cerebrospinal fluid Humans Inactivation Infectious Diseases Lesions Metabolic Diseases Molecular Medicine Molecular weight Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Neurons - drug effects Neurosciences Oligopeptides - isolation & purification Oligopeptides - pharmacology Patients pentapeptides Peptides Sequence Analysis, Protein Sodium sodium antagonists Sodium Channel Blockers Tumor Cells, Cultured
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