Attenuation of angiotensin II-mediated coronary vasoconstriction and vasodilatory action of angiotensin-converting enzyme inhibitor in pacing-induced heart failure in dogs

OBJECTIVES We investigated the changes in coronary vascular resistance caused by angiotensin II, angiotensin-converting enzyme (ACE) inhibition and angiotensin II type 1 or 2 receptor (AT1R and AT2R, respectively) antagonists in chronic heart failure (CHF). BACKGROUND Angiotensin II is an intense va...

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Veröffentlicht in:	Journal of the American College of Cardiology 2001-10, Vol.38 (4), p.1188-1194
Hauptverfasser:	Oikawa, Yuji, Maehara, Kazuhira, Saito, Tomiyoshi, Tamagawa, Kazuaki, Maruyama, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - physiology Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Bradykinin - antagonists & inhibitors Cardiology. Vascular system Coronary Vessels - physiology Dogs Female Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hemodynamics - drug effects Male Medical sciences Vascular Resistance - drug effects Vasodilation - drug effects
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