Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status
Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its possible suppression by the antiaging action of dietary restriction...
Gespeichert in:
| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2001-10, Vol.56 (10), p.B426-B431 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | B431 |
|---|---|
| container_issue | 10 |
| container_start_page | B426 |
| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
| container_volume | 56 |
| creator | Baek, B S Kim, J W Lee, J H Kwon, H J Kim, N D Kang, H S Yoo, M A Yu, B P Chung, H Y |
| description | Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats. |
| doi_str_mv | 10.1093/gerona/56.10.B426 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71219381</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>85566660</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-f262da368612339f6c8b73b2dbf61b86256de534d4f77005a06b61f36eea29373</originalsourceid><addsrcrecordid>eNpdUE1Lw0AQXUSxtfoDvEjw4C3tfmR3k2MtfkHBi4K3uMlOypYkW3eT0vx7N7QgOJeZN7z3mHkI3RI8Jzhjiw0426oFFwHOHxMqztCUSJ7GnPGv8zBjmcUcYzFBV95v8VicXqIJITxNMJVT9L3cQOygVh3oyLSlA-UhslVUOGXaqBzK2trDsIF23KuyM3vTDZFqdaQNdMoNUWN1H_TGtqPOHowOYA-R71TX-2t0Uanaw82pz9Dn89PH6jVev7-8rZbruGSSdnFFBdWKiVQQylhWiTItJCuoLipBilRQLjRwluikkjJ8obAoBKmYAFA0Y5LN0MPRd-fsTw--yxvjS6hr1YLtfS4JJRlLSSDe_yNube_acFtOcSoYS7IskMiRVDrrvYMq3znThG9zgvMx-_yYfc7FuBmzD5q7k3FfNKD_FKew2S8heIHF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>208633499</pqid></control><display><type>article</type><title>Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><creator>Baek, B S ; Kim, J W ; Lee, J H ; Kwon, H J ; Kim, N D ; Kang, H S ; Yoo, M A ; Yu, B P ; Chung, H Y</creator><creatorcontrib>Baek, B S ; Kim, J W ; Lee, J H ; Kwon, H J ; Kim, N D ; Kang, H S ; Yoo, M A ; Yu, B P ; Chung, H Y</creatorcontrib><description>Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/56.10.B426</identifier><identifier>PMID: 11584027</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Age Factors ; Aging ; Aging - physiology ; Animals ; Base Sequence ; Blotting, Western ; Brain ; Culture Techniques ; Diet ; Dinoprostone - metabolism ; Experiments ; Male ; Medical research ; Models, Animal ; Molecular Sequence Data ; Neurons ; Polymerase Chain Reaction ; Prostaglandin-Endoperoxide Synthases - metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; RNA, Messenger - analysis ; Rodents ; Sensitivity and Specificity ; Telencephalon - enzymology</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2001-10, Vol.56 (10), p.B426-B431</ispartof><rights>Copyright Gerontological Society of America, Incorporated Oct 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f262da368612339f6c8b73b2dbf61b86256de534d4f77005a06b61f36eea29373</citedby><cites>FETCH-LOGICAL-c372t-f262da368612339f6c8b73b2dbf61b86256de534d4f77005a06b61f36eea29373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11584027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baek, B S</creatorcontrib><creatorcontrib>Kim, J W</creatorcontrib><creatorcontrib>Lee, J H</creatorcontrib><creatorcontrib>Kwon, H J</creatorcontrib><creatorcontrib>Kim, N D</creatorcontrib><creatorcontrib>Kang, H S</creatorcontrib><creatorcontrib>Yoo, M A</creatorcontrib><creatorcontrib>Yu, B P</creatorcontrib><creatorcontrib>Chung, H Y</creatorcontrib><title>Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Blotting, Western</subject><subject>Brain</subject><subject>Culture Techniques</subject><subject>Diet</subject><subject>Dinoprostone - metabolism</subject><subject>Experiments</subject><subject>Male</subject><subject>Medical research</subject><subject>Models, Animal</subject><subject>Molecular Sequence Data</subject><subject>Neurons</subject><subject>Polymerase Chain Reaction</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>Rodents</subject><subject>Sensitivity and Specificity</subject><subject>Telencephalon - enzymology</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUE1Lw0AQXUSxtfoDvEjw4C3tfmR3k2MtfkHBi4K3uMlOypYkW3eT0vx7N7QgOJeZN7z3mHkI3RI8Jzhjiw0426oFFwHOHxMqztCUSJ7GnPGv8zBjmcUcYzFBV95v8VicXqIJITxNMJVT9L3cQOygVh3oyLSlA-UhslVUOGXaqBzK2trDsIF23KuyM3vTDZFqdaQNdMoNUWN1H_TGtqPOHowOYA-R71TX-2t0Uanaw82pz9Dn89PH6jVev7-8rZbruGSSdnFFBdWKiVQQylhWiTItJCuoLipBilRQLjRwluikkjJ8obAoBKmYAFA0Y5LN0MPRd-fsTw--yxvjS6hr1YLtfS4JJRlLSSDe_yNube_acFtOcSoYS7IskMiRVDrrvYMq3znThG9zgvMx-_yYfc7FuBmzD5q7k3FfNKD_FKew2S8heIHF</recordid><startdate>200110</startdate><enddate>200110</enddate><creator>Baek, B S</creator><creator>Kim, J W</creator><creator>Lee, J H</creator><creator>Kwon, H J</creator><creator>Kim, N D</creator><creator>Kang, H S</creator><creator>Yoo, M A</creator><creator>Yu, B P</creator><creator>Chung, H Y</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200110</creationdate><title>Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status</title><author>Baek, B S ; Kim, J W ; Lee, J H ; Kwon, H J ; Kim, N D ; Kang, H S ; Yoo, M A ; Yu, B P ; Chung, H Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-f262da368612339f6c8b73b2dbf61b86256de534d4f77005a06b61f36eea29373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Blotting, Western</topic><topic>Brain</topic><topic>Culture Techniques</topic><topic>Diet</topic><topic>Dinoprostone - metabolism</topic><topic>Experiments</topic><topic>Male</topic><topic>Medical research</topic><topic>Models, Animal</topic><topic>Molecular Sequence Data</topic><topic>Neurons</topic><topic>Polymerase Chain Reaction</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>Rodents</topic><topic>Sensitivity and Specificity</topic><topic>Telencephalon - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baek, B S</creatorcontrib><creatorcontrib>Kim, J W</creatorcontrib><creatorcontrib>Lee, J H</creatorcontrib><creatorcontrib>Kwon, H J</creatorcontrib><creatorcontrib>Kim, N D</creatorcontrib><creatorcontrib>Kang, H S</creatorcontrib><creatorcontrib>Yoo, M A</creatorcontrib><creatorcontrib>Yu, B P</creatorcontrib><creatorcontrib>Chung, H Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baek, B S</au><au>Kim, J W</au><au>Lee, J H</au><au>Kwon, H J</au><au>Kim, N D</au><au>Kang, H S</au><au>Yoo, M A</au><au>Yu, B P</au><au>Chung, H Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2001-10</date><risdate>2001</risdate><volume>56</volume><issue>10</issue><spage>B426</spage><epage>B431</epage><pages>B426-B431</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanism of the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24 months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due to the activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant status in aged rats.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>11584027</pmid><doi>10.1093/gerona/56.10.B426</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2001-10, Vol.56 (10), p.B426-B431 |
| issn | 1079-5006 1758-535X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71219381 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Age Factors Aging Aging - physiology Animals Base Sequence Blotting, Western Brain Culture Techniques Diet Dinoprostone - metabolism Experiments Male Medical research Models, Animal Molecular Sequence Data Neurons Polymerase Chain Reaction Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Wistar Reactive Oxygen Species - metabolism RNA, Messenger - analysis Rodents Sensitivity and Specificity Telencephalon - enzymology |
| title | Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T15%3A48%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20increase%20of%20brain%20cyclooxygenase%20activity%20and%20dietary%20modulation%20of%20oxidative%20status&rft.jtitle=The%20journals%20of%20gerontology.%20Series%20A,%20Biological%20sciences%20and%20medical%20sciences&rft.au=Baek,%20B%20S&rft.date=2001-10&rft.volume=56&rft.issue=10&rft.spage=B426&rft.epage=B431&rft.pages=B426-B431&rft.issn=1079-5006&rft.eissn=1758-535X&rft_id=info:doi/10.1093/gerona/56.10.B426&rft_dat=%3Cproquest_cross%3E85566660%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=208633499&rft_id=info:pmid/11584027&rfr_iscdi=true |