Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo

The spatial and temporal expression of the protein-tyrosine kinase B (TrkB) receptor and its ligands has been correlated with the development of the neocortex. Activation of the receptor has been associated with neocortical neuronal survival, differentiation, connectivity and neurotransmitter releas...

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Veröffentlicht in:	Neuroscience 2000-01, Vol.98 (3), p.437-447
Hauptverfasser:	Gates, M.A, Tai, C.C, Macklis, J.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Tissue Transplantation Carbocyanines cell culture Cell Differentiation - genetics Cell Size - genetics Cell Survival - physiology Cells, Cultured Cerebral Ventricles - growth & development Cerebral Ventricles - pathology Corpus Callosum - growth & development Corpus Callosum - pathology Development. Senescence. Regeneration. Transplantation DiI tract tracing Female Fluorescent Dyes Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genotype immunocytochemistry In Vitro Techniques Male Mice Mice, Knockout Neocortex - growth & development Neocortex - pathology neocortical development Neural Pathways neural transplantation Neurites - chemistry Neurites - pathology Neurons - pathology Neurons - transplantation Neurons - ultrastructure Receptor, trkB - genetics TrkB −/− mutant mice Vertebrates: nervous system and sense organs
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