Parkin and the Molecular Pathways of Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implic...

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Veröffentlicht in:	Neuron 2001-09, Vol.31 (6), p.885-888
Hauptverfasser:	Giasson, Benoit I., Lee, Virginia M.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Amino Acid Motifs Animals Chromosomes, Human, Pair 6 - genetics Cysteine Endopeptidases - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Genetic Predisposition to Disease Humans Lewy Bodies - metabolism Ligases - deficiency Ligases - genetics Ligases - physiology Mice Mice, Transgenic Models, Biological Multienzyme Complexes - metabolism Mutation Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Oxidative Stress parkin gene Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson Disease - metabolism Proteasome Endopeptidase Complex Protein Folding Rats Structure-Activity Relationship Substantia Nigra - metabolism Synucleins Ubiquitin - physiology Ubiquitin-Protein Ligases
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