Post-antibiotic effect of the antimicrobial peptide lactoferricin on Escherichia coli and Staphylococcus aureus
Lactoferricin is an antimicrobial peptide generated by gastric pepsin cleavage of lactoferrin. A possible post-antibiotic effect (PAE) of bovine lactoferricin (Lfcin B) and two shorter peptide derivatives against Staphylococcus aureus and Escherichia coli was studied. A drug removal technique involv...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2001-10, Vol.48 (4), p.569-571 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Haukland, Hanne H. Vorland, Lars H. |
| description | Lactoferricin is an antimicrobial peptide generated by gastric pepsin cleavage of lactoferrin. A possible post-antibiotic effect (PAE) of bovine lactoferricin (Lfcin B) and two shorter peptide derivatives against Staphylococcus aureus and Escherichia coli was studied. A drug removal technique involving centrifugation and washing was used. No PAE was found for Lfcin B against these two bacteria. The shorter derivatives had a short PAE against E. coli. They had a short negative PAE against S. aureus. In conclusion, the overall PAE is not overwhelming, but the small differences found between the different peptide–bacteria combinations could indicate that different peptide mechanisms of action might be present. |
| doi_str_mv | 10.1093/jac/48.4.569 |
| format | Article |
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A possible post-antibiotic effect (PAE) of bovine lactoferricin (Lfcin B) and two shorter peptide derivatives against Staphylococcus aureus and Escherichia coli was studied. A drug removal technique involving centrifugation and washing was used. No PAE was found for Lfcin B against these two bacteria. The shorter derivatives had a short PAE against E. coli. They had a short negative PAE against S. aureus. In conclusion, the overall PAE is not overwhelming, but the small differences found between the different peptide–bacteria combinations could indicate that different peptide mechanisms of action might be present.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/48.4.569</identifier><identifier>PMID: 11581240</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cattle ; Escherichia coli - drug effects ; Escherichia coli - growth & development ; Humans ; Lactoferrin - analogs & derivatives ; Lactoferrin - chemistry ; Lactoferrin - pharmacology ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Peptides - chemical synthesis ; Peptides - chemistry ; Peptides - pharmacology ; Pharmacology. Drug treatments ; Sequence Analysis, Protein ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - growth & development</subject><ispartof>Journal of antimicrobial chemotherapy, 2001-10, Vol.48 (4), p.569-571</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Oct 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-22ca1adf1a4cbbdac172e4f1dc0c87d43d1ce20b05a1006737227d8f9df17feb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14071651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11581240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haukland, Hanne H.</creatorcontrib><creatorcontrib>Vorland, Lars H.</creatorcontrib><title>Post-antibiotic effect of the antimicrobial peptide lactoferricin on Escherichia coli and Staphylococcus aureus</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>Lactoferricin is an antimicrobial peptide generated by gastric pepsin cleavage of lactoferrin. A possible post-antibiotic effect (PAE) of bovine lactoferricin (Lfcin B) and two shorter peptide derivatives against Staphylococcus aureus and Escherichia coli was studied. A drug removal technique involving centrifugation and washing was used. No PAE was found for Lfcin B against these two bacteria. The shorter derivatives had a short PAE against E. coli. They had a short negative PAE against S. aureus. In conclusion, the overall PAE is not overwhelming, but the small differences found between the different peptide–bacteria combinations could indicate that different peptide mechanisms of action might be present.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - growth & development</subject><subject>Humans</subject><subject>Lactoferrin - analogs & derivatives</subject><subject>Lactoferrin - chemistry</subject><subject>Lactoferrin - pharmacology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Sequence Data</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Sequence Analysis, Protein</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - growth & development</subject><issn>0305-7453</issn><issn>1460-2091</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0VGLEzEQB_AgildP33yWIOiT28tks8n2UcrVEw8sqHD4ErKzCU3dbtYkC963N6XFA1_0KYT5zcDMn5CXwJbAVvXV3uCVaJdi2cjVI7IAIVnF2QoekwWrWVMp0dQX5FlKe8aYbGT7lFwANC1wwRYkbEPKlRmz73zIHql1zmKmwdG8s_RYOHiMofNmoJOdsu8tHQzm4GyMHv1Iw0ivE-5s-e28oRgGX_p6-iWbaXc_BAyIc6JmjnZOz8kTZ4ZkX5zfS_Jtc_11fVPdfv7wcf3-tkIhRK44RwOmd2AEdl1vEBS3wkGPDFvVi7oHtJx1rDFQtlK14lz1rVuVFuVsV1-St6e5Uww_Z5uyPviEdhjMaMOctAJeLiWbf0JoJYBc_Q8USjHJC3z9F9yHOY5lW81BSQUtrwt6d0LltilF6_QU_cHEew1MH3PVJVctWi10ybXwV-eZc3ew_QM-B1nAmzMwCc3gohnRpwcnmALZQHHVyfmU7a8_dRN_6OMVG31z913D3Wa73rJPelP_BtCdu6Q</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Haukland, Hanne H.</creator><creator>Vorland, Lars H.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Post-antibiotic effect of the antimicrobial peptide lactoferricin on Escherichia coli and Staphylococcus aureus</title><author>Haukland, Hanne H. ; Vorland, Lars H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-22ca1adf1a4cbbdac172e4f1dc0c87d43d1ce20b05a1006737227d8f9df17feb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - growth & development</topic><topic>Humans</topic><topic>Lactoferrin - analogs & derivatives</topic><topic>Lactoferrin - chemistry</topic><topic>Lactoferrin - pharmacology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Sequence Data</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - chemistry</topic><topic>Peptides - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Sequence Analysis, Protein</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haukland, Hanne H.</creatorcontrib><creatorcontrib>Vorland, Lars H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haukland, Hanne H.</au><au>Vorland, Lars H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-antibiotic effect of the antimicrobial peptide lactoferricin on Escherichia coli and Staphylococcus aureus</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J. Antimicrob. Chemother</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>48</volume><issue>4</issue><spage>569</spage><epage>571</epage><pages>569-571</pages><issn>0305-7453</issn><issn>1460-2091</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Lactoferricin is an antimicrobial peptide generated by gastric pepsin cleavage of lactoferrin. A possible post-antibiotic effect (PAE) of bovine lactoferricin (Lfcin B) and two shorter peptide derivatives against Staphylococcus aureus and Escherichia coli was studied. A drug removal technique involving centrifugation and washing was used. No PAE was found for Lfcin B against these two bacteria. The shorter derivatives had a short PAE against E. coli. They had a short negative PAE against S. aureus. In conclusion, the overall PAE is not overwhelming, but the small differences found between the different peptide–bacteria combinations could indicate that different peptide mechanisms of action might be present.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11581240</pmid><doi>10.1093/jac/48.4.569</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cattle Escherichia coli - drug effects Escherichia coli - growth & development Humans Lactoferrin - analogs & derivatives Lactoferrin - chemistry Lactoferrin - pharmacology Medical sciences Microbial Sensitivity Tests Molecular Sequence Data Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Pharmacology. Drug treatments Sequence Analysis, Protein Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development |
| title | Post-antibiotic effect of the antimicrobial peptide lactoferricin on Escherichia coli and Staphylococcus aureus |
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