Substance P induces tumor necrosis factor-α release from human skin via mitogen-activated protein kinase

Substance P plays an important role in neurogenic inflammation with granulocyte infiltration. To investigate cytokines involved in the substance P-induced inflammation and the mechanism of cell activation, we studied the release of TNF (tumor necrosis factor)-α and histamine from human skin slices i...

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Veröffentlicht in:	European journal of pharmacology 2000-06, Vol.398 (2), p.309-315
Hauptverfasser:	Okabe, Tsutomu, Hide, Michihiro, Koro, Osamu, Yamamoto, Shoso
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Dexamethasone Dexamethasone - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Flavonoids - pharmacology General aspects Histamine Histamine Release - drug effects Humans Imidazoles - pharmacology Immunopathology In Vitro Techniques Male MAP (mitogen-activated protein) kinase Medical sciences Middle Aged Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Pyridines - pharmacology Skin Skin - drug effects Skin - metabolism Substance P Substance P - pharmacology TNF-α (tumor necrosis factor-α) Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism
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