Identification of a 60S Preribosomal Particle that Is Closely Linked to Nuclear Export

A nuclear GTPase, Nug1p, was identified in a genetic screen for components linked to 60S ribosomal subunit export. Nug1p cosedimented with nuclear 60S preribosomes and was required for subunit export to the cytoplasm. Tagged Nug1p coprecipitated with proteins of the 60S subunit, late precursors to t...

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Veröffentlicht in:	Molecular cell 2001-09, Vol.8 (3), p.517-529
Hauptverfasser:	Baßler, Jochen, Grandi, Paola, Gadal, Olivier, Leßmann, Torben, Petfalski, Elisabeth, Tollervey, David, Lechner, Johannes, Hurt, Ed
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Amino Acid Sequence Animals Blotting, Northern Cell Nucleus - metabolism Centrifugation, Density Gradient Fungal Proteins - genetics Fungal Proteins - metabolism Genes, Reporter - genetics GTP Phosphohydrolases - chemistry GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Molecular Sequence Data Noc2 protein Noc3 protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Nug1 protein Nug2 protein Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Ribosomal Proteins - genetics Ribosomal Proteins - metabolism ribosomal subunit 60S Ribosomes - chemistry Ribosomes - metabolism Rix1 protein Rlp7 protein Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Sequence Alignment Temperature Transformation, Genetic Ylr106 protein
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