Matrix Metalloproteinase 9 and the Epidermal Growth Factor Signal Pathway in Operable Non-Small Cell Lung Cancer

Matrix metalloproteinase (MMP)-9 is an endopeptidase that digests basement membrane type IV collagen. Enhanced expression has been related to tumor progression both in vitro and in vivo . The control of MMP transcription is complex, but recently, epidermal growth factor receptor (EGFR) expression ha...

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Veröffentlicht in:	Clinical cancer research 2000-06, Vol.6 (6), p.2349-2355
Hauptverfasser:	COX, G, JONES, J. L, O'BYRNE, K. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - surgery Adult Age Factors Aged Biological and medical sciences Carcinoma, Large Cell - diagnosis Carcinoma, Large Cell - metabolism Carcinoma, Large Cell - surgery Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - surgery Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - surgery Cell Membrane - metabolism Cytoplasm - metabolism Disease Progression Epidermal Growth Factor - biosynthesis Female Humans Immunohistochemistry Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Lung Neoplasms - surgery Male Matrix Metalloproteinase 9 - biosynthesis Medical sciences Middle Aged Multivariate Analysis Pneumology Prognosis Retrospective Studies Sex Factors Signal Transduction Time Factors Tumors of the respiratory system and mediastinum Up-Regulation
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