Halichondrin B:  Synthesis of the C(1)−C(15) Subunit

A short and efficient synthesis of the C(1)−C(15) subunit of halichondrin B in its natural configuration is described. The polycyclic caged ketal 3, containing nine asymmetric centers, is prepared in 14 steps from α-d-glucoheptonic acid γ-lactone (7). Key steps in the two similar routes described in...

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Veröffentlicht in:	Journal of organic chemistry 2000-06, Vol.65 (13), p.4070-4087
Hauptverfasser:	Burke, Steven D, Jung, Kyung Woon, Lambert, William T, Phillips, Jeannie R, Klovning, Jason J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Ethers, Cyclic - chemical synthesis Ethers, Cyclic - chemistry Indicators and Reagents Macrolides Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation
Online-Zugang:	Volltext
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