EGFR overexpression and radiation response in glioblastoma multiforme

Recent studies have suggested relative radioresistance in glioblastoma multiforme (GM) tumors in older patients, consistent with their shorter survival. Two common molecular genetic abnormalities in GM are age related: epidermal growth factor receptor (EGFR) overexpression in older patients and p53...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2001-10, Vol.51 (2), p.410-418
Hauptverfasser:	BARKER, Fred G, SIMMONS, Martha L, ALDAPE, Ken D, CHANG, Susan M, PRADOS, Michael D, LARSON, David A, SNEED, Penny K, WARA, William M, BERGER, Mitchel S, PENGCHIN CHEN, ISRAEL, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Analysis of Variance Biological and medical sciences Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - radiotherapy Diseases of the nervous system ErbB Receptors - metabolism Female Genes, p53 - genetics Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - radiotherapy Humans Male Medical sciences Middle Aged Neoplasm Proteins - metabolism Neurology Odds Ratio Prospective Studies Radiotherapy Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Regression Analysis Supratentorial Neoplasms - genetics Supratentorial Neoplasms - metabolism Supratentorial Neoplasms - radiotherapy Tumors of the nervous system. Phacomatoses
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