Regio- and Stereoselective Cycloadditions of Cyclic Nitrones to Maleic Diamide Forced in a Peptide:  Synthesis of Potent Ligands of Human NK-2 Receptor

The regioselectivity and the stereoselectivity induced by relatively small peptidomimetic maleic diamide 1 in cycloaddition reactions with cyclic nitrones 2−5 was studied. The high regio- and stereoselectivity observed, sensibly increased by nonpolar solvents, was the effect of a double-asymmetric i...

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Veröffentlicht in:	Journal of organic chemistry 2000-06, Vol.65 (13), p.4003-4008
Hauptverfasser:	Valenza, Silvia, Cordero, Franca M, Brandi, Alberto, Guidi, Antonio, Altamura, Maria, Giolitti, Alessandro, Giuntini, Francesca, Pasqui, Franco, Renzetti, Anna Rita, Maggi, Carlo Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Dipeptides - chemistry Dipeptides - pharmacokinetics Humans Indicators and Reagents Ligands Models, Molecular Molecular Conformation Nitrogen Oxides - chemical synthesis Nitrogen Oxides - chemistry Nitrogen Oxides - pharmacokinetics Receptors, Neurokinin-2 - metabolism Structure-Activity Relationship Tachykinins - chemistry
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