Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases
We investigated clinicopathologically the pyramidal signs, including spasticity, hyperreflexia, and Babinski's sign, and the involvement of the pyramidal tract and primary motor cortex, in seven Japanese autopsy cases of multiple system atrophy (MSA). Pyramidal signs were observed in six (86%)...
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| Veröffentlicht in: | Acta neuropathologica 2000-06, Vol.99 (6), p.628-636 |
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| creator | Tsuchiya, K Ozawa, E Haga, C Watabiki, S Ikeda, M Sano, M Ooe, K Taki, K Ikeda, K |
| description | We investigated clinicopathologically the pyramidal signs, including spasticity, hyperreflexia, and Babinski's sign, and the involvement of the pyramidal tract and primary motor cortex, in seven Japanese autopsy cases of multiple system atrophy (MSA). Pyramidal signs were observed in six (86%) of the seven autopsy cases. Hyperreflexia and Babinski's sign were each evident in five patients, but spasticity was observed in only one patient. Loss of Betz cells and presence of glial cytoplasmic inclusions in the primary motor cortex were noticed in all seven cases. Astrocytosis in the fifth layer of the primary motor cortex was noticed in five cases, but its presence was not related to the duration of the disease. Involvement of the pyramidal tract in the spinal cord, particularly of the small myelinated fibers, was observed in all seven cases, but no involvement of the pyramidal tract in the midbrain was evident in any of the six cases in which this structure was examined. In MSA, pyramidal signs were shown to be present more frequently than believed before, and the clinicopathological correlation between pyramidal signs and involvement of the pyramidal tract was obvious. Constant involvement of Betz cells in MSA has not been reported. Our clinicopathological findings may also make a contribution to the understanding of the clinicopathological hallmarks of MSA. |
| doi_str_mv | 10.1007/s004010051173 |
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Pyramidal signs were observed in six (86%) of the seven autopsy cases. Hyperreflexia and Babinski's sign were each evident in five patients, but spasticity was observed in only one patient. Loss of Betz cells and presence of glial cytoplasmic inclusions in the primary motor cortex were noticed in all seven cases. Astrocytosis in the fifth layer of the primary motor cortex was noticed in five cases, but its presence was not related to the duration of the disease. Involvement of the pyramidal tract in the spinal cord, particularly of the small myelinated fibers, was observed in all seven cases, but no involvement of the pyramidal tract in the midbrain was evident in any of the six cases in which this structure was examined. In MSA, pyramidal signs were shown to be present more frequently than believed before, and the clinicopathological correlation between pyramidal signs and involvement of the pyramidal tract was obvious. Constant involvement of Betz cells in MSA has not been reported. Our clinicopathological findings may also make a contribution to the understanding of the clinicopathological hallmarks of MSA.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010051173</identifier><identifier>PMID: 10867796</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Atrophy ; Autopsy ; Cortex (motor) ; Female ; Gliosis ; Humans ; Inclusion bodies ; Male ; Mesencephalon ; Middle Aged ; Motor Cortex - pathology ; Motor Cortex - physiopathology ; Multiple System Atrophy - pathology ; Multiple System Atrophy - physiopathology ; Neurologic Examination ; Pyramidal Cells - pathology ; Pyramidal Tracts - pathology ; Pyramidal Tracts - physiopathology ; Signs ; Spasticity ; Spinal cord</subject><ispartof>Acta neuropathologica, 2000-06, Vol.99 (6), p.628-636</ispartof><rights>Springer-Verlag Berlin Heidelberg 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-7f95aa0401f22813d4e5c68b93d0a9088706edf984d29db8d29e8d160a4b90023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10867796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuchiya, K</creatorcontrib><creatorcontrib>Ozawa, E</creatorcontrib><creatorcontrib>Haga, C</creatorcontrib><creatorcontrib>Watabiki, S</creatorcontrib><creatorcontrib>Ikeda, M</creatorcontrib><creatorcontrib>Sano, M</creatorcontrib><creatorcontrib>Ooe, K</creatorcontrib><creatorcontrib>Taki, K</creatorcontrib><creatorcontrib>Ikeda, K</creatorcontrib><title>Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>We investigated clinicopathologically the pyramidal signs, including spasticity, hyperreflexia, and Babinski's sign, and the involvement of the pyramidal tract and primary motor cortex, in seven Japanese autopsy cases of multiple system atrophy (MSA). Pyramidal signs were observed in six (86%) of the seven autopsy cases. Hyperreflexia and Babinski's sign were each evident in five patients, but spasticity was observed in only one patient. Loss of Betz cells and presence of glial cytoplasmic inclusions in the primary motor cortex were noticed in all seven cases. Astrocytosis in the fifth layer of the primary motor cortex was noticed in five cases, but its presence was not related to the duration of the disease. Involvement of the pyramidal tract in the spinal cord, particularly of the small myelinated fibers, was observed in all seven cases, but no involvement of the pyramidal tract in the midbrain was evident in any of the six cases in which this structure was examined. In MSA, pyramidal signs were shown to be present more frequently than believed before, and the clinicopathological correlation between pyramidal signs and involvement of the pyramidal tract was obvious. Constant involvement of Betz cells in MSA has not been reported. Our clinicopathological findings may also make a contribution to the understanding of the clinicopathological hallmarks of MSA.</description><subject>Atrophy</subject><subject>Autopsy</subject><subject>Cortex (motor)</subject><subject>Female</subject><subject>Gliosis</subject><subject>Humans</subject><subject>Inclusion bodies</subject><subject>Male</subject><subject>Mesencephalon</subject><subject>Middle Aged</subject><subject>Motor Cortex - pathology</subject><subject>Motor Cortex - physiopathology</subject><subject>Multiple System Atrophy - pathology</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Neurologic Examination</subject><subject>Pyramidal Cells - pathology</subject><subject>Pyramidal Tracts - pathology</subject><subject>Pyramidal Tracts - physiopathology</subject><subject>Signs</subject><subject>Spasticity</subject><subject>Spinal cord</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1v1DAQhi0EokvhyBVZQuotMLaT2OEGq9IiVeLSniOvPWFTOXHwOCuFf8C_JtH2AFzmQ3rm1cy8jL0V8EEA6I8EUMJaVUJo9YztRKlkAZVSz9kOAERRKykv2Cuix7WTuqxesgsBpta6qXfs9z6OlO2YeT-eYjjhgGsdO56PyL9g_sUdhkDcjp5PS7JD723gOVm3TfBhDrmfAnJaKOPAbU5xOi6fuOUu9GPv4mTzMYb4o3frHOXZL5s64QlHbuccJ1q4s4T0mr3obCB885Qv2cPX6_v9bXH3_ebb_vNd4ZRRudBdU1m73dxJaYTyJVauNodGebANGKOhRt81pvSy8QezRjRe1GDLQwMg1SW7OutOKf6ckXI79LQdaUeMM7VayO07G_j-P_Axzmlcd2tlKSotpQS1UsWZcikSJezaKfWDTUsroN0cav9xaOXfPanOhwH9X_TZEvUH-DKMzA</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Tsuchiya, K</creator><creator>Ozawa, E</creator><creator>Haga, C</creator><creator>Watabiki, S</creator><creator>Ikeda, M</creator><creator>Sano, M</creator><creator>Ooe, K</creator><creator>Taki, K</creator><creator>Ikeda, K</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases</title><author>Tsuchiya, K ; Ozawa, E ; Haga, C ; Watabiki, S ; Ikeda, M ; Sano, M ; Ooe, K ; Taki, K ; Ikeda, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-7f95aa0401f22813d4e5c68b93d0a9088706edf984d29db8d29e8d160a4b90023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Atrophy</topic><topic>Autopsy</topic><topic>Cortex (motor)</topic><topic>Female</topic><topic>Gliosis</topic><topic>Humans</topic><topic>Inclusion bodies</topic><topic>Male</topic><topic>Mesencephalon</topic><topic>Middle Aged</topic><topic>Motor Cortex - pathology</topic><topic>Motor Cortex - physiopathology</topic><topic>Multiple System Atrophy - pathology</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>Neurologic Examination</topic><topic>Pyramidal Cells - pathology</topic><topic>Pyramidal Tracts - pathology</topic><topic>Pyramidal Tracts - physiopathology</topic><topic>Signs</topic><topic>Spasticity</topic><topic>Spinal cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuchiya, K</creatorcontrib><creatorcontrib>Ozawa, E</creatorcontrib><creatorcontrib>Haga, C</creatorcontrib><creatorcontrib>Watabiki, S</creatorcontrib><creatorcontrib>Ikeda, M</creatorcontrib><creatorcontrib>Sano, M</creatorcontrib><creatorcontrib>Ooe, K</creatorcontrib><creatorcontrib>Taki, K</creatorcontrib><creatorcontrib>Ikeda, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuchiya, K</au><au>Ozawa, E</au><au>Haga, C</au><au>Watabiki, S</au><au>Ikeda, M</au><au>Sano, M</au><au>Ooe, K</au><au>Taki, K</au><au>Ikeda, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>99</volume><issue>6</issue><spage>628</spage><epage>636</epage><pages>628-636</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><abstract>We investigated clinicopathologically the pyramidal signs, including spasticity, hyperreflexia, and Babinski's sign, and the involvement of the pyramidal tract and primary motor cortex, in seven Japanese autopsy cases of multiple system atrophy (MSA). Pyramidal signs were observed in six (86%) of the seven autopsy cases. Hyperreflexia and Babinski's sign were each evident in five patients, but spasticity was observed in only one patient. Loss of Betz cells and presence of glial cytoplasmic inclusions in the primary motor cortex were noticed in all seven cases. Astrocytosis in the fifth layer of the primary motor cortex was noticed in five cases, but its presence was not related to the duration of the disease. Involvement of the pyramidal tract in the spinal cord, particularly of the small myelinated fibers, was observed in all seven cases, but no involvement of the pyramidal tract in the midbrain was evident in any of the six cases in which this structure was examined. In MSA, pyramidal signs were shown to be present more frequently than believed before, and the clinicopathological correlation between pyramidal signs and involvement of the pyramidal tract was obvious. Constant involvement of Betz cells in MSA has not been reported. Our clinicopathological findings may also make a contribution to the understanding of the clinicopathological hallmarks of MSA.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>10867796</pmid><doi>10.1007/s004010051173</doi><tpages>9</tpages></addata></record> |
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| subjects | Atrophy Autopsy Cortex (motor) Female Gliosis Humans Inclusion bodies Male Mesencephalon Middle Aged Motor Cortex - pathology Motor Cortex - physiopathology Multiple System Atrophy - pathology Multiple System Atrophy - physiopathology Neurologic Examination Pyramidal Cells - pathology Pyramidal Tracts - pathology Pyramidal Tracts - physiopathology Signs Spasticity Spinal cord |
| title | Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases |
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