A Novel Human Metalloprotease Synthesized in the Liver and Secreted into the Blood: Possibly, the von Willebrand Factor—Cleaving Protease?

We identified a novel metalloprotease, which could be responsible for cleaving the Tyr842-Met843 peptide bond of von Willebrand factor (vWF). This metalloprotease was purified from Conn Fraction-I precipitate of human pooled plasma by the combination of gel filtration, DEAE chromatography, and prepa...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2001-10, Vol.130 (4), p.475-480
Hauptverfasser:	Soejima, Kenji, Mimura, Noriko, Hiroshima, Masaki, Maeda, Hiroaki, Hamamoto, Takayoshi, Nakagaki, Tomohiro, Nozaki, Chikateru
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins ADAMTS ADAMTS13 Protein Alternative Splicing Amino Acid Motifs Amino Acid Sequence Base Sequence Chromosome Mapping Cloning, Molecular disintegrin-like Disintegrins - chemistry Humans Liver - enzymology Metalloendopeptidases - biosynthesis Metalloendopeptidases - genetics Metalloendopeptidases - metabolism metalloprotease Molecular Sequence Data Protein Isoforms - genetics Protein Structure, Tertiary RNA, Messenger - biosynthesis throm-botic thrombocytopenic purpura Thrombospondin 1 - chemistry thrombospondin type-1 Tissue Distribution Transcription, Genetic von Willebrand factor von Willebrand Factor - metabolism vWF-cleaving protease
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