Monoamine oxidase inhibitory activity of some Hypericum species native to South Brazil
The total methanol crude extracts and petroleum ether, chloroform, and methanol fractions obtained from Hypericum species, H. caprifoliatum, H. carinatum, H. connatum, H. cordatum, H. myrianthum, H. piriai, H. polyanthemum and H. brasiliense, all native to South Brazil, were assayed for monoamine ox...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2001-09, Vol.53 (9), p.1273-1279 |
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| container_title | Journal of pharmacy and pharmacology |
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| creator | Gnerre, Carmela von Poser, Gilsane L. Ferraz, Alexandre Viana, Alice Testa, Bernard Rates, Stela M. K. |
| description | The total methanol crude extracts and petroleum ether, chloroform, and methanol fractions obtained from Hypericum species, H. caprifoliatum, H. carinatum, H. connatum, H. cordatum, H. myrianthum, H. piriai, H. polyanthemum and H. brasiliense, all native to South Brazil, were assayed for monoamine oxidase A (MAO A) and MAO B inhibitory activity in rat brain mitochondrial preparations at concentrations ranging from 1 to 20 μg mL−1. Three benzo‐pyrans, HP1 (6‐isobutyryl‐5,7‐dimethoxy‐2,2‐dimethylbenzopyran), HP2 (7‐hydroxy‐6‐iso‐butyryl‐5‐methoxy‐2,2‐dimethylbenzopyran) and HP3 (5‐hydroxy‐6‐isobutyryl‐7‐methoxy‐2,2‐dimethylbenzopyran) isolated from H. polyanthemum were also tested at maximal concentrations of 150, 150 and 75 μ, respectively. The lipophilic extracts of H. polyanthemum, H. caprifoliatum and H. piriai displayed MAO A inhibitory activity greater than 50%. Among the benzopyrans, only HP3 showed significant activity, with an IC50 value of 22 μ. The total methanol crude extracts of aerial parts from H. carinatum, H. connatum, H. cordatum, H. polyanthemum and H. piriai were evaluated for antidepressant activity in the Porsolt's forced swimming test in Wistar rats (270 mg kg−1 day−1; i.p); however, none of them showed activity. |
| doi_str_mv | 10.1211/0022357011776568 |
| format | Article |
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The lipophilic extracts of H. polyanthemum, H. caprifoliatum and H. piriai displayed MAO A inhibitory activity greater than 50%. Among the benzopyrans, only HP3 showed significant activity, with an IC50 value of 22 μ. The total methanol crude extracts of aerial parts from H. carinatum, H. connatum, H. cordatum, H. polyanthemum and H. piriai were evaluated for antidepressant activity in the Porsolt's forced swimming test in Wistar rats (270 mg kg−1 day−1; i.p); however, none of them showed activity.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/0022357011776568</identifier><identifier>PMID: 11578110</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antidepressive Agents - pharmacology ; Brain ; Brazil ; Depression - drug therapy ; Disease Models, Animal ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; Hypericum - chemistry ; Mitochondria - enzymology ; Monoamine Oxidase - metabolism ; Monoamine Oxidase Inhibitors - isolation & purification ; Monoamine Oxidase Inhibitors - pharmacology ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Swimming</subject><ispartof>Journal of pharmacy and pharmacology, 2001-09, Vol.53 (9), p.1273-1279</ispartof><rights>2001 Royal Pharmaceutical Society of Great Britain</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4225-5676c5a67128300366c3df8ebddb98e4c23ac4db1948b6417496a8c695125db53</citedby><cites>FETCH-LOGICAL-c4225-5676c5a67128300366c3df8ebddb98e4c23ac4db1948b6417496a8c695125db53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1211%2F0022357011776568$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1211%2F0022357011776568$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11578110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gnerre, Carmela</creatorcontrib><creatorcontrib>von Poser, Gilsane L.</creatorcontrib><creatorcontrib>Ferraz, Alexandre</creatorcontrib><creatorcontrib>Viana, Alice</creatorcontrib><creatorcontrib>Testa, Bernard</creatorcontrib><creatorcontrib>Rates, Stela M. K.</creatorcontrib><title>Monoamine oxidase inhibitory activity of some Hypericum species native to South Brazil</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>The total methanol crude extracts and petroleum ether, chloroform, and methanol fractions obtained from Hypericum species, H. caprifoliatum, H. carinatum, H. connatum, H. cordatum, H. myrianthum, H. piriai, H. polyanthemum and H. brasiliense, all native to South Brazil, were assayed for monoamine oxidase A (MAO A) and MAO B inhibitory activity in rat brain mitochondrial preparations at concentrations ranging from 1 to 20 μg mL−1. Three benzo‐pyrans, HP1 (6‐isobutyryl‐5,7‐dimethoxy‐2,2‐dimethylbenzopyran), HP2 (7‐hydroxy‐6‐iso‐butyryl‐5‐methoxy‐2,2‐dimethylbenzopyran) and HP3 (5‐hydroxy‐6‐isobutyryl‐7‐methoxy‐2,2‐dimethylbenzopyran) isolated from H. polyanthemum were also tested at maximal concentrations of 150, 150 and 75 μ, respectively. The lipophilic extracts of H. polyanthemum, H. caprifoliatum and H. piriai displayed MAO A inhibitory activity greater than 50%. Among the benzopyrans, only HP3 showed significant activity, with an IC50 value of 22 μ. The total methanol crude extracts of aerial parts from H. carinatum, H. connatum, H. cordatum, H. polyanthemum and H. piriai were evaluated for antidepressant activity in the Porsolt's forced swimming test in Wistar rats (270 mg kg−1 day−1; i.p); however, none of them showed activity.</description><subject>Animals</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Brain</subject><subject>Brazil</subject><subject>Depression - drug therapy</subject><subject>Disease Models, Animal</subject><subject>Enzyme Inhibitors - isolation & purification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Hypericum - chemistry</subject><subject>Mitochondria - enzymology</subject><subject>Monoamine Oxidase - metabolism</subject><subject>Monoamine Oxidase Inhibitors - isolation & purification</subject><subject>Monoamine Oxidase Inhibitors - pharmacology</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Swimming</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9v1DAQhS0Eokvhzgn5xC3gseNxcqRb2gUVKOLX0XKcWdWQxIudQMNfT1a7AokLpzm873saPcYeg3gGEuC5EFIqbQSAMaixusNWUpSyMKCru2y1j4slVyfsQc5fhRAGEe-zEwBtKgCxYp_fxCG6PgzE421oXSYehpvQhDGmmTs_hh9hnHnc8hx74pt5Ryn4qed5Rz5Q5oNbEOJj5B_iNN7ws-R-he4hu7d1XaZHx3vKPl28_LjeFFfvLl-tX1wVvpRSFxoNeu3QgKyUEArRq3ZbUdO2TV1R6aVyvmwbqMuqwRJMWaOrPNYapG4brU7Z00PvLsXvE-XR9iF76jo3UJyyXYoFotqD4gD6FHNOtLW7FHqXZgvC7re0_265KE-O3VPTU_tXOI63AHgAfoaO5v8W2tfXm2sw9f6Z4iCGPNLtH9GlbxaNMtp-eXtpz87fr_UFnNtS_Qa_Yoyp</recordid><startdate>200109</startdate><enddate>200109</enddate><creator>Gnerre, Carmela</creator><creator>von Poser, Gilsane L.</creator><creator>Ferraz, Alexandre</creator><creator>Viana, Alice</creator><creator>Testa, Bernard</creator><creator>Rates, Stela M. 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K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gnerre, Carmela</au><au>von Poser, Gilsane L.</au><au>Ferraz, Alexandre</au><au>Viana, Alice</au><au>Testa, Bernard</au><au>Rates, Stela M. 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Three benzo‐pyrans, HP1 (6‐isobutyryl‐5,7‐dimethoxy‐2,2‐dimethylbenzopyran), HP2 (7‐hydroxy‐6‐iso‐butyryl‐5‐methoxy‐2,2‐dimethylbenzopyran) and HP3 (5‐hydroxy‐6‐isobutyryl‐7‐methoxy‐2,2‐dimethylbenzopyran) isolated from H. polyanthemum were also tested at maximal concentrations of 150, 150 and 75 μ, respectively. The lipophilic extracts of H. polyanthemum, H. caprifoliatum and H. piriai displayed MAO A inhibitory activity greater than 50%. Among the benzopyrans, only HP3 showed significant activity, with an IC50 value of 22 μ. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Antidepressive Agents - pharmacology Brain Brazil Depression - drug therapy Disease Models, Animal Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Hypericum - chemistry Mitochondria - enzymology Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - isolation & purification Monoamine Oxidase Inhibitors - pharmacology Plant Extracts - pharmacology Rats Rats, Wistar Swimming |
| title | Monoamine oxidase inhibitory activity of some Hypericum species native to South Brazil |
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