Accelerated Replicative Senescence of Medial Smooth Muscle Cells Derived from Abdominal Aortic Aneurysms Compared to the Adjacent Inferior Mesenteric Artery

Background. Abdominal aortic aneurysms (AAAs) are associated with aging and atherosclerosis. AAAs arise through a degenerative process characterized in part by depletion of medial smooth muscle cells (SMC), suggesting that generalized aging and SMC senescence represent potential mechanisms contribut...

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Veröffentlicht in:	The Journal of surgical research 2000-07, Vol.92 (1), p.85-95
Hauptverfasser:	Liao, Shixiong, Curci, John A., Kelley, Brian J., Sicard, Gregorio A., Thompson, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	abdominal aortic aneurysm Aged Aged, 80 and over aging Aorta, Abdominal - cytology Aortic Aneurysm, Abdominal - pathology apoptosis Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system cell culture Cell Division - drug effects Cell Division - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - physiology Culture Media, Conditioned - pharmacology Diseases of the aorta DNA - biosynthesis Female Flow Cytometry Growth Substances - metabolism Humans Male Medical sciences Mesenteric Arteries - cytology Middle Aged Muscle, Smooth, Vascular - cytology replicative senescence Solubility vascular smooth muscle cells
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