Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis
Morphogenesis and cell differentiation in multicellular organisms often require accurate control of cell divisions. We show that a novel cell cycle regulator, tribbles, is critical for this control during Drosophila development. During oogenesis, the level of tribbles affects the number of germ cell...
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| Veröffentlicht in: | Cell 2000-05, Vol.101 (5), p.511-522 |
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| creator | Mata, Juan Curado, Silvia Ephrussi, Anne Rørth, Pernille |
| description | Morphogenesis and cell differentiation in multicellular organisms often require accurate control of cell divisions. We show that a novel cell cycle regulator,
tribbles, is critical for this control during
Drosophila development. During oogenesis, the level of
tribbles affects the number of germ cell divisions as well as oocyte determination. The mesoderm anlage enters mitosis prematurely in
tribbles mutant embryos, leading to gastrulation defects. We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway. By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination. |
| doi_str_mv | 10.1016/S0092-8674(00)80861-2 |
| format | Article |
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tribbles, is critical for this control during
Drosophila development. During oogenesis, the level of
tribbles affects the number of germ cell divisions as well as oocyte determination. The mesoderm anlage enters mitosis prematurely in
tribbles mutant embryos, leading to gastrulation defects. We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway. By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(00)80861-2</identifier><identifier>PMID: 10850493</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; cdc25 Phosphatases - metabolism ; cdc25 protein ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell Cycle Proteins - physiology ; Drosophila ; Drosophila - embryology ; Drosophila - physiology ; Drosophila Proteins ; Female ; G2 Phase ; gastrulation ; Genes, Insect ; Insect Proteins - genetics ; Insect Proteins - metabolism ; Insect Proteins - physiology ; Mitosis - physiology ; Morphogenesis ; Ovary - embryology ; Phosphoprotein Phosphatases - metabolism ; Protein Tyrosine Phosphatases ; Protein-Serine-Threonine Kinases ; string protein ; Transfection ; Tribbles protein</subject><ispartof>Cell, 2000-05, Vol.101 (5), p.511-522</ispartof><rights>2000 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-bb69feaa272376a811cf0c99c17ba3b7c440d59af464df639f193e3dcbac82693</citedby><cites>FETCH-LOGICAL-c557t-bb69feaa272376a811cf0c99c17ba3b7c440d59af464df639f193e3dcbac82693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0092-8674(00)80861-2$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10850493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mata, Juan</creatorcontrib><creatorcontrib>Curado, Silvia</creatorcontrib><creatorcontrib>Ephrussi, Anne</creatorcontrib><creatorcontrib>Rørth, Pernille</creatorcontrib><title>Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis</title><title>Cell</title><addtitle>Cell</addtitle><description>Morphogenesis and cell differentiation in multicellular organisms often require accurate control of cell divisions. We show that a novel cell cycle regulator,
tribbles, is critical for this control during
Drosophila development. During oogenesis, the level of
tribbles affects the number of germ cell divisions as well as oocyte determination. The mesoderm anlage enters mitosis prematurely in
tribbles mutant embryos, leading to gastrulation defects. We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway. By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination.</description><subject>Animals</subject><subject>cdc25 Phosphatases - metabolism</subject><subject>cdc25 protein</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Cycle Proteins - physiology</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - physiology</subject><subject>Drosophila Proteins</subject><subject>Female</subject><subject>G2 Phase</subject><subject>gastrulation</subject><subject>Genes, Insect</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Insect Proteins - physiology</subject><subject>Mitosis - physiology</subject><subject>Morphogenesis</subject><subject>Ovary - embryology</subject><subject>Phosphoprotein Phosphatases - metabolism</subject><subject>Protein Tyrosine Phosphatases</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>string protein</subject><subject>Transfection</subject><subject>Tribbles protein</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9P3DAQxa2Kqiy0H6EoJ1QOKWMntuMTQuFfpV21KvRs2c5kMcrGi52ttN--Xhah3jjNaPR7M5r3CPlK4TsFKs7vARQrGyHrbwBnDTSCluwDmVFQsqypZAdk9oYckqOUngCg4Zx_Ioc0N1CrakbcQ_TWDpiKNoTY-dFMuV_4KSSfCjN2xSLE9WNY4oi7iR-LqxhSWD_6wRR2W_zG5WYwkx-Xxf0Uczlvr1rGi18xTBiGbRZ9Jh97MyT88lqPyZ-b64f2rpz_vP3RXs5Lx7mcSmuF6tEYJlklhWkodT04pRyV1lRWurqGjivT16LuelGpnqoKq85Z4xomVHVMTvd71zE8bzBNeuWTw2EwI4ZN0pIyEEzKd0Eqec0agAzyPejyzylir9fRr0zcagp6F4N-iUHvPNYA-iUGzbLu5PXAxq6w-0-19z0DF3sAsx9_PUadnMfRYecjukl3wb9z4h_kepg1</recordid><startdate>20000526</startdate><enddate>20000526</enddate><creator>Mata, Juan</creator><creator>Curado, Silvia</creator><creator>Ephrussi, Anne</creator><creator>Rørth, Pernille</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20000526</creationdate><title>Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis</title><author>Mata, Juan ; 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We show that a novel cell cycle regulator,
tribbles, is critical for this control during
Drosophila development. During oogenesis, the level of
tribbles affects the number of germ cell divisions as well as oocyte determination. The mesoderm anlage enters mitosis prematurely in
tribbles mutant embryos, leading to gastrulation defects. We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway. By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10850493</pmid><doi>10.1016/S0092-8674(00)80861-2</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Animals cdc25 Phosphatases - metabolism cdc25 protein Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Drosophila Drosophila - embryology Drosophila - physiology Drosophila Proteins Female G2 Phase gastrulation Genes, Insect Insect Proteins - genetics Insect Proteins - metabolism Insect Proteins - physiology Mitosis - physiology Morphogenesis Ovary - embryology Phosphoprotein Phosphatases - metabolism Protein Tyrosine Phosphatases Protein-Serine-Threonine Kinases string protein Transfection Tribbles protein |
| title | Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis |
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