Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population
Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population. C L Rohlfing , R R Little , H M Wiedmeyer , J D England , R Madsen , M I Harris , K M Flegal , M S Eberhardt and D E Goldstein Department of Child Health, University of Missouri School of Medicine, Columbia 65203, USA....
Gespeichert in:
| Veröffentlicht in: | Diabetes care 2000-02, Vol.23 (2), p.187-191 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 191 |
|---|---|
| container_issue | 2 |
| container_start_page | 187 |
| container_title | Diabetes care |
| container_volume | 23 |
| creator | ROHLFING, C. L LITTLE, R. R WIEDMEYER, H.-M ENGLAND, J. D MADSEN, R HARRIS, M. I FLEGAL, K. M EBERHARDT, M. S GOLDSTEIN, D. E |
| description | Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population.
C L Rohlfing ,
R R Little ,
H M Wiedmeyer ,
J D England ,
R Madsen ,
M I Harris ,
K M Flegal ,
M S Eberhardt and
D E Goldstein
Department of Child Health, University of Missouri School of Medicine, Columbia 65203, USA. rohlfingc@health.missouri.edu
Abstract
OBJECTIVE: To evaluate the use of GHb as a screening test for undiagnosed diabetes (fasting plasma glucose > or =7.0 mmol/l)
in a representative sample of the U.S. population. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination
Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican Americans aged > or =20 years. Of
these subjects, 7,832 participated in a morning examination session, of which 1,273 were excluded because of a previous diagnosis
of diabetes, missing data, or fasting time of |
| doi_str_mv | 10.2337/diacare.23.2.187 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71205779</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A59650603</galeid><sourcerecordid>A59650603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4837-b9e07b7e6477628d51f7c352e73c4d410333c2e2e63d2882a598e18b454fd8903</originalsourceid><addsrcrecordid>eNptkc2LFDEQxYMo7jh69yRBRFyw23x2kuOw6I6wsAedc5NOV89k6UnGpJvF_94sPaLokkOlil_Ve_AQek1JzThXn3pvnU1QmprVVKsnaEUNl5WUQj9FK0KFqaQx7AK9yPmOECKE1s_RBSW60ZqZFbrdZcBxwNfbDn_YdhvqLrEPOLsEEHzY4yEmPIcitA8xQ4_Lr4MJ8gM1HQDv6m81PsXTPNrJx_ASPRvsmOHVua7R7svn71fb6ub2-uvV5qZyQnNVdQaI6hQ0QqmG6V7SQTkuGSjuRC8o4Zw7Bgwa3rPi1EqjgepOSDH02hC-Ru-Xu6cUf8yQp_bos4NxtAHinFtFGZFKmQK-_Qe8i3MKxVvLGCdSkGJojT4u0N6O0PowxClZt4cAyY4xwODLeCNNI0lTrK1R9QheXg9H7x7jycK7FHNOMLSn5I82_WwpaR-CbM9BlqZlbQmyrLw52567I_R_LSzJFeDdGbDZ2XFINjif_3BcaKVFwS4X7OD3h3tfJH4H-L_mL1cdsYE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223054048</pqid></control><display><type>article</type><title>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>ROHLFING, C. L ; LITTLE, R. R ; WIEDMEYER, H.-M ; ENGLAND, J. D ; MADSEN, R ; HARRIS, M. I ; FLEGAL, K. M ; EBERHARDT, M. S ; GOLDSTEIN, D. E</creator><creatorcontrib>ROHLFING, C. L ; LITTLE, R. R ; WIEDMEYER, H.-M ; ENGLAND, J. D ; MADSEN, R ; HARRIS, M. I ; FLEGAL, K. M ; EBERHARDT, M. S ; GOLDSTEIN, D. E</creatorcontrib><description>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population.
C L Rohlfing ,
R R Little ,
H M Wiedmeyer ,
J D England ,
R Madsen ,
M I Harris ,
K M Flegal ,
M S Eberhardt and
D E Goldstein
Department of Child Health, University of Missouri School of Medicine, Columbia 65203, USA. rohlfingc@health.missouri.edu
Abstract
OBJECTIVE: To evaluate the use of GHb as a screening test for undiagnosed diabetes (fasting plasma glucose > or =7.0 mmol/l)
in a representative sample of the U.S. population. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination
Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican Americans aged > or =20 years. Of
these subjects, 7,832 participated in a morning examination session, of which 1,273 were excluded because of a previous diagnosis
of diabetes, missing data, or fasting time of <8 h before examination. Venous blood was obtained to measure fasting plasma
glucose and GHb in the remaining 6,559 subjects. Receiver operating characteristic curve analysis was used to examine the
sensitivity and specificity of GHb for detecting diabetes at increasing GHb cutoff levels. RESULTS: GHb demonstrated high
sensitivity (83.4%) and specificity (84.4%) for detecting undiagnosed diabetes at a GHb cutoff of 1 SD above the normal mean.
Moderate sensitivity (63.2%) and very high specificity (97.4%) were evident at a GHb cutoff of 2 SD above the normal mean.
Sensitivity at this level ranged from 58.6% in the non-Hispanic white population to 83.6% in the Mexican-American population;
specificity ranged from 93.0% in the nonHispanic black population to 98.3% in the non-Hispanic white population. CONCLUSIONS:
GHb is a highly specific and convenient alternative to fasting plasma glucose for diabetes screening. A GHb value of 2 SD
above the normal mean could identify a high proportion of individuals with undiagnosed diabetes who are at risk for developing
diabetes complications.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.23.2.187</identifier><identifier>PMID: 10868829</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biomarkers - blood ; Black or African American ; Black People ; Blood Glucose - analysis ; Diabetes ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Diagnosis ; Functional investigation of endocrine glands and genital system ; Gamma-hydroxybutyrate ; Glucose ; Glucose tolerance tests ; Glycated Hemoglobin - analysis ; Health Surveys ; Hispanic or Latino ; Hispanic people ; Humans ; Innovations ; Investigative techniques, diagnostic techniques (general aspects) ; Mass Screening - methods ; Medical sciences ; Medical screening ; Mexican Americans ; Middle Aged ; Nutrition Surveys ; Plasma ; Regression Analysis ; ROC Curve ; Sensitivity and Specificity ; United States - epidemiology ; White People</subject><ispartof>Diabetes care, 2000-02, Vol.23 (2), p.187-191</ispartof><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 2000 American Diabetes Association</rights><rights>Copyright American Diabetes Association Feb 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4837-b9e07b7e6477628d51f7c352e73c4d410333c2e2e63d2882a598e18b454fd8903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1348784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10868829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROHLFING, C. L</creatorcontrib><creatorcontrib>LITTLE, R. R</creatorcontrib><creatorcontrib>WIEDMEYER, H.-M</creatorcontrib><creatorcontrib>ENGLAND, J. D</creatorcontrib><creatorcontrib>MADSEN, R</creatorcontrib><creatorcontrib>HARRIS, M. I</creatorcontrib><creatorcontrib>FLEGAL, K. M</creatorcontrib><creatorcontrib>EBERHARDT, M. S</creatorcontrib><creatorcontrib>GOLDSTEIN, D. E</creatorcontrib><title>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population.
C L Rohlfing ,
R R Little ,
H M Wiedmeyer ,
J D England ,
R Madsen ,
M I Harris ,
K M Flegal ,
M S Eberhardt and
D E Goldstein
Department of Child Health, University of Missouri School of Medicine, Columbia 65203, USA. rohlfingc@health.missouri.edu
Abstract
OBJECTIVE: To evaluate the use of GHb as a screening test for undiagnosed diabetes (fasting plasma glucose > or =7.0 mmol/l)
in a representative sample of the U.S. population. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination
Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican Americans aged > or =20 years. Of
these subjects, 7,832 participated in a morning examination session, of which 1,273 were excluded because of a previous diagnosis
of diabetes, missing data, or fasting time of <8 h before examination. Venous blood was obtained to measure fasting plasma
glucose and GHb in the remaining 6,559 subjects. Receiver operating characteristic curve analysis was used to examine the
sensitivity and specificity of GHb for detecting diabetes at increasing GHb cutoff levels. RESULTS: GHb demonstrated high
sensitivity (83.4%) and specificity (84.4%) for detecting undiagnosed diabetes at a GHb cutoff of 1 SD above the normal mean.
Moderate sensitivity (63.2%) and very high specificity (97.4%) were evident at a GHb cutoff of 2 SD above the normal mean.
Sensitivity at this level ranged from 58.6% in the non-Hispanic white population to 83.6% in the Mexican-American population;
specificity ranged from 93.0% in the nonHispanic black population to 98.3% in the non-Hispanic white population. CONCLUSIONS:
GHb is a highly specific and convenient alternative to fasting plasma glucose for diabetes screening. A GHb value of 2 SD
above the normal mean could identify a high proportion of individuals with undiagnosed diabetes who are at risk for developing
diabetes complications.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diagnosis</subject><subject>Functional investigation of endocrine glands and genital system</subject><subject>Gamma-hydroxybutyrate</subject><subject>Glucose</subject><subject>Glucose tolerance tests</subject><subject>Glycated Hemoglobin - analysis</subject><subject>Health Surveys</subject><subject>Hispanic or Latino</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Innovations</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Mexican Americans</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Plasma</subject><subject>Regression Analysis</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>United States - epidemiology</subject><subject>White People</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc2LFDEQxYMo7jh69yRBRFyw23x2kuOw6I6wsAedc5NOV89k6UnGpJvF_94sPaLokkOlil_Ve_AQek1JzThXn3pvnU1QmprVVKsnaEUNl5WUQj9FK0KFqaQx7AK9yPmOECKE1s_RBSW60ZqZFbrdZcBxwNfbDn_YdhvqLrEPOLsEEHzY4yEmPIcitA8xQ4_Lr4MJ8gM1HQDv6m81PsXTPNrJx_ASPRvsmOHVua7R7svn71fb6ub2-uvV5qZyQnNVdQaI6hQ0QqmG6V7SQTkuGSjuRC8o4Zw7Bgwa3rPi1EqjgepOSDH02hC-Ru-Xu6cUf8yQp_bos4NxtAHinFtFGZFKmQK-_Qe8i3MKxVvLGCdSkGJojT4u0N6O0PowxClZt4cAyY4xwODLeCNNI0lTrK1R9QheXg9H7x7jycK7FHNOMLSn5I82_WwpaR-CbM9BlqZlbQmyrLw52567I_R_LSzJFeDdGbDZ2XFINjif_3BcaKVFwS4X7OD3h3tfJH4H-L_mL1cdsYE</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>ROHLFING, C. L</creator><creator>LITTLE, R. R</creator><creator>WIEDMEYER, H.-M</creator><creator>ENGLAND, J. D</creator><creator>MADSEN, R</creator><creator>HARRIS, M. I</creator><creator>FLEGAL, K. M</creator><creator>EBERHARDT, M. S</creator><creator>GOLDSTEIN, D. E</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200002</creationdate><title>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population</title><author>ROHLFING, C. L ; LITTLE, R. R ; WIEDMEYER, H.-M ; ENGLAND, J. D ; MADSEN, R ; HARRIS, M. I ; FLEGAL, K. M ; EBERHARDT, M. S ; GOLDSTEIN, D. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4837-b9e07b7e6477628d51f7c352e73c4d410333c2e2e63d2882a598e18b454fd8903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diagnosis</topic><topic>Functional investigation of endocrine glands and genital system</topic><topic>Gamma-hydroxybutyrate</topic><topic>Glucose</topic><topic>Glucose tolerance tests</topic><topic>Glycated Hemoglobin - analysis</topic><topic>Health Surveys</topic><topic>Hispanic or Latino</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Innovations</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Mexican Americans</topic><topic>Middle Aged</topic><topic>Nutrition Surveys</topic><topic>Plasma</topic><topic>Regression Analysis</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>United States - epidemiology</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROHLFING, C. L</creatorcontrib><creatorcontrib>LITTLE, R. R</creatorcontrib><creatorcontrib>WIEDMEYER, H.-M</creatorcontrib><creatorcontrib>ENGLAND, J. D</creatorcontrib><creatorcontrib>MADSEN, R</creatorcontrib><creatorcontrib>HARRIS, M. I</creatorcontrib><creatorcontrib>FLEGAL, K. M</creatorcontrib><creatorcontrib>EBERHARDT, M. S</creatorcontrib><creatorcontrib>GOLDSTEIN, D. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROHLFING, C. L</au><au>LITTLE, R. R</au><au>WIEDMEYER, H.-M</au><au>ENGLAND, J. D</au><au>MADSEN, R</au><au>HARRIS, M. I</au><au>FLEGAL, K. M</au><au>EBERHARDT, M. S</au><au>GOLDSTEIN, D. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2000-02</date><risdate>2000</risdate><volume>23</volume><issue>2</issue><spage>187</spage><epage>191</epage><pages>187-191</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population.
C L Rohlfing ,
R R Little ,
H M Wiedmeyer ,
J D England ,
R Madsen ,
M I Harris ,
K M Flegal ,
M S Eberhardt and
D E Goldstein
Department of Child Health, University of Missouri School of Medicine, Columbia 65203, USA. rohlfingc@health.missouri.edu
Abstract
OBJECTIVE: To evaluate the use of GHb as a screening test for undiagnosed diabetes (fasting plasma glucose > or =7.0 mmol/l)
in a representative sample of the U.S. population. RESEARCH DESIGN AND METHODS: The Third National Health and Nutrition Examination
Survey included national samples of non-Hispanic whites, non-Hispanic blacks, and Mexican Americans aged > or =20 years. Of
these subjects, 7,832 participated in a morning examination session, of which 1,273 were excluded because of a previous diagnosis
of diabetes, missing data, or fasting time of <8 h before examination. Venous blood was obtained to measure fasting plasma
glucose and GHb in the remaining 6,559 subjects. Receiver operating characteristic curve analysis was used to examine the
sensitivity and specificity of GHb for detecting diabetes at increasing GHb cutoff levels. RESULTS: GHb demonstrated high
sensitivity (83.4%) and specificity (84.4%) for detecting undiagnosed diabetes at a GHb cutoff of 1 SD above the normal mean.
Moderate sensitivity (63.2%) and very high specificity (97.4%) were evident at a GHb cutoff of 2 SD above the normal mean.
Sensitivity at this level ranged from 58.6% in the non-Hispanic white population to 83.6% in the Mexican-American population;
specificity ranged from 93.0% in the nonHispanic black population to 98.3% in the non-Hispanic white population. CONCLUSIONS:
GHb is a highly specific and convenient alternative to fasting plasma glucose for diabetes screening. A GHb value of 2 SD
above the normal mean could identify a high proportion of individuals with undiagnosed diabetes who are at risk for developing
diabetes complications.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>10868829</pmid><doi>10.2337/diacare.23.2.187</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2000-02, Vol.23 (2), p.187-191 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71205779 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Biological and medical sciences Biomarkers - blood Black or African American Black People Blood Glucose - analysis Diabetes Diabetes Mellitus - blood Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Diagnosis Functional investigation of endocrine glands and genital system Gamma-hydroxybutyrate Glucose Glucose tolerance tests Glycated Hemoglobin - analysis Health Surveys Hispanic or Latino Hispanic people Humans Innovations Investigative techniques, diagnostic techniques (general aspects) Mass Screening - methods Medical sciences Medical screening Mexican Americans Middle Aged Nutrition Surveys Plasma Regression Analysis ROC Curve Sensitivity and Specificity United States - epidemiology White People |
| title | Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A49%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20GHb%20(HbA1c)%20in%20screening%20for%20undiagnosed%20diabetes%20in%20the%20U.S.%20population&rft.jtitle=Diabetes%20care&rft.au=ROHLFING,%20C.%20L&rft.date=2000-02&rft.volume=23&rft.issue=2&rft.spage=187&rft.epage=191&rft.pages=187-191&rft.issn=0149-5992&rft.eissn=1935-5548&rft.coden=DICAD2&rft_id=info:doi/10.2337/diacare.23.2.187&rft_dat=%3Cgale_proqu%3EA59650603%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223054048&rft_id=info:pmid/10868829&rft_galeid=A59650603&rfr_iscdi=true |