Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis

Ankylosing spondylitis (AS) is a common and highly familial rheumatic disorder. The sibling recurrence risk ratio for the disease is 63 and heritability assessed in twins >90%. Although MHC genes, including HLA-B27, contribute only 20-50% of the genetic risk for the disease, no non-MHC gene has y...

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Veröffentlicht in:	Human molecular genetics 2000-07, Vol.9 (11), p.1563-1566
Hauptverfasser:	BROWN, M. A, EDWARDS, S, WORDSWORTH, B. P, HOYLE, E, CAMPBELL, S, LAVAL, S, DALY, A. K, PILE, K. D, CALIN, A, EBRINGER, A, WEEKS, D. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Case-Control Studies chromosome 22 CYP2D6 gene Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism debrisoquine hydroxylase Diseases of the osteoarticular system DNA - genetics Family Health Female Genetic Linkage Genetic Predisposition to Disease Genotype HLA-B27 gene Humans Inflammatory joint diseases Lod Score Male Medical sciences Nuclear Family Polymorphism, Genetic Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - pathology
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