Allograft loss in renal transplant recipients with Fabry's disease and activated protein C resistance
Fabry's disease is associated with an increased incidence of thrombotic events and rejection. Spontaneous thrombosis of a functioning cadaveric renal allograft in a recipient with Fabry's disease prompted prospective evaluation of all transplant candidates with Fabry's disease for hyp...
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| Veröffentlicht in: | Transplantation 2000-05, Vol.69 (10), p.2099-2102 |
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| creator | FRIEDMAN, G. S WIK, D JACOBS, M SILVA, L ABDOU, J. C MEIER-KRIESCHE, H. U KAPLAN, B BONOMINI, L DEFRANCO, P LYMAN, N MULGAONKAR, S |
| description | Fabry's disease is associated with an increased incidence of thrombotic events and rejection. Spontaneous thrombosis of a functioning cadaveric renal allograft in a recipient with Fabry's disease prompted prospective evaluation of all transplant candidates with Fabry's disease for hypercoagulability.
Transplant candidates with Fabry's disease were tested for hypercoagulability, analyzed for HLA-type and ABO group, and comorbid conditions suggestive of hypercoagulability.
A unique association of Fabry's disease with activated protein C Resistance was documented in a cohort of Caucasian male renal transplant recipients with Fabry's disease. Four of five patients were blood group A and had no significant comorbid conditions suggestive of hypercoagulability. The resistance to activation of protein C (APCR)(+) patients shared HLA loci-B8 and Dr3, although the APCR(-) patients shared HLA loci-B27 and -B38.
Due to the observed increase in the incidence of APCR in our Fabry's cohort, we suggest screening all patients with Fabry's disease for APCR. Because factor V and factor Va receptors are found on vascular endothelium and peripheral blood monocytes, APCR in the presence of Fabry's disease may be a nonimmunological stimulus for rejection. Analysis of HLA typing in patients with Fabry's disease may further elucidate HLA-based association of Fabry's disease and resistance to activated protein C with the risk of thrombosis and rejection. |
| doi_str_mv | 10.1097/00007890-200005270-00022 |
| format | Article |
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Transplant candidates with Fabry's disease were tested for hypercoagulability, analyzed for HLA-type and ABO group, and comorbid conditions suggestive of hypercoagulability.
A unique association of Fabry's disease with activated protein C Resistance was documented in a cohort of Caucasian male renal transplant recipients with Fabry's disease. Four of five patients were blood group A and had no significant comorbid conditions suggestive of hypercoagulability. The resistance to activation of protein C (APCR)(+) patients shared HLA loci-B8 and Dr3, although the APCR(-) patients shared HLA loci-B27 and -B38.
Due to the observed increase in the incidence of APCR in our Fabry's cohort, we suggest screening all patients with Fabry's disease for APCR. Because factor V and factor Va receptors are found on vascular endothelium and peripheral blood monocytes, APCR in the presence of Fabry's disease may be a nonimmunological stimulus for rejection. Analysis of HLA typing in patients with Fabry's disease may further elucidate HLA-based association of Fabry's disease and resistance to activated protein C with the risk of thrombosis and rejection.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-200005270-00022</identifier><identifier>PMID: 10852604</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>ABO Blood-Group System ; Activated Protein C Resistance - complications ; Activated Protein C Resistance - immunology ; Adult ; Biological and medical sciences ; Cohort Studies ; Comorbidity ; European Continental Ancestry Group ; Fabry Disease - complications ; Fabry Disease - immunology ; Histocompatibility Testing ; HLA-B Antigens - analysis ; HLA-B27 Antigen - analysis ; HLA-B38 Antigen ; HLA-B8 Antigen - analysis ; HLA-DR3 Antigen - analysis ; Humans ; Kidney Transplantation - immunology ; Male ; Medical sciences ; Middle Aged ; protein C ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Transplantation, Homologous ; Treatment Failure</subject><ispartof>Transplantation, 2000-05, Vol.69 (10), p.2099-2102</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1417276$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10852604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRIEDMAN, G. S</creatorcontrib><creatorcontrib>WIK, D</creatorcontrib><creatorcontrib>JACOBS, M</creatorcontrib><creatorcontrib>SILVA, L</creatorcontrib><creatorcontrib>ABDOU, J. C</creatorcontrib><creatorcontrib>MEIER-KRIESCHE, H. U</creatorcontrib><creatorcontrib>KAPLAN, B</creatorcontrib><creatorcontrib>BONOMINI, L</creatorcontrib><creatorcontrib>DEFRANCO, P</creatorcontrib><creatorcontrib>LYMAN, N</creatorcontrib><creatorcontrib>MULGAONKAR, S</creatorcontrib><title>Allograft loss in renal transplant recipients with Fabry's disease and activated protein C resistance</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Fabry's disease is associated with an increased incidence of thrombotic events and rejection. Spontaneous thrombosis of a functioning cadaveric renal allograft in a recipient with Fabry's disease prompted prospective evaluation of all transplant candidates with Fabry's disease for hypercoagulability.
Transplant candidates with Fabry's disease were tested for hypercoagulability, analyzed for HLA-type and ABO group, and comorbid conditions suggestive of hypercoagulability.
A unique association of Fabry's disease with activated protein C Resistance was documented in a cohort of Caucasian male renal transplant recipients with Fabry's disease. Four of five patients were blood group A and had no significant comorbid conditions suggestive of hypercoagulability. The resistance to activation of protein C (APCR)(+) patients shared HLA loci-B8 and Dr3, although the APCR(-) patients shared HLA loci-B27 and -B38.
Due to the observed increase in the incidence of APCR in our Fabry's cohort, we suggest screening all patients with Fabry's disease for APCR. Because factor V and factor Va receptors are found on vascular endothelium and peripheral blood monocytes, APCR in the presence of Fabry's disease may be a nonimmunological stimulus for rejection. Analysis of HLA typing in patients with Fabry's disease may further elucidate HLA-based association of Fabry's disease and resistance to activated protein C with the risk of thrombosis and rejection.</description><subject>ABO Blood-Group System</subject><subject>Activated Protein C Resistance - complications</subject><subject>Activated Protein C Resistance - immunology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>European Continental Ancestry Group</subject><subject>Fabry Disease - complications</subject><subject>Fabry Disease - immunology</subject><subject>Histocompatibility Testing</subject><subject>HLA-B Antigens - analysis</subject><subject>HLA-B27 Antigen - analysis</subject><subject>HLA-B38 Antigen</subject><subject>HLA-B8 Antigen - analysis</subject><subject>HLA-DR3 Antigen - analysis</subject><subject>Humans</subject><subject>Kidney Transplantation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>protein C</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Transplantation, Homologous</subject><subject>Treatment Failure</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMhiMEYmPwF1AOCE6FfLRNc0QTA6RJXOBcuakLQVlX6gy0f08mhjjiiy378Sv7ZYxLcS2FNTcihamsyNSuKpQRWcpKHbCpLHSelaISh2wqRC4zqbWZsBOi9x2qjTlmEymqQpUinzK8DWH9OkIXeVgTcd_zEXsIPI7Q0xCgj6nh_OCxj8S_fHzjC2jG7RXx1hMCIYe-5eCi_4SILR_GdcQkM0975ClC7_CUHXUQCM_2ecZeFnfP84ds-XT_OL9dZoMqTcykK6HJ0ZYdoi5MZYpS28KZrunaRjTWQdUKaKW1VqRJpxU6RKEkWqsTq2fs8kc3HfGxQYr1ypPDkN7A9YZqI5XIK_s_KE2y0CiZwPM9uGlW2NbD6FcwbutfBxNwsQeAHIQu2eY8_XG5NMqU-huKhYG6</recordid><startdate>20000527</startdate><enddate>20000527</enddate><creator>FRIEDMAN, G. S</creator><creator>WIK, D</creator><creator>JACOBS, M</creator><creator>SILVA, L</creator><creator>ABDOU, J. C</creator><creator>MEIER-KRIESCHE, H. U</creator><creator>KAPLAN, B</creator><creator>BONOMINI, L</creator><creator>DEFRANCO, P</creator><creator>LYMAN, N</creator><creator>MULGAONKAR, S</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000527</creationdate><title>Allograft loss in renal transplant recipients with Fabry's disease and activated protein C resistance</title><author>FRIEDMAN, G. S ; WIK, D ; JACOBS, M ; SILVA, L ; ABDOU, J. C ; MEIER-KRIESCHE, H. U ; KAPLAN, B ; BONOMINI, L ; DEFRANCO, P ; LYMAN, N ; MULGAONKAR, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p267t-1c6ab4e96fee3578756395c7fbfdb0b9ca8d0ad19990639f32ecee021e9935633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>ABO Blood-Group System</topic><topic>Activated Protein C Resistance - complications</topic><topic>Activated Protein C Resistance - immunology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>European Continental Ancestry Group</topic><topic>Fabry Disease - complications</topic><topic>Fabry Disease - immunology</topic><topic>Histocompatibility Testing</topic><topic>HLA-B Antigens - analysis</topic><topic>HLA-B27 Antigen - analysis</topic><topic>HLA-B38 Antigen</topic><topic>HLA-B8 Antigen - analysis</topic><topic>HLA-DR3 Antigen - analysis</topic><topic>Humans</topic><topic>Kidney Transplantation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>protein C</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Transplantation, Homologous</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRIEDMAN, G. S</creatorcontrib><creatorcontrib>WIK, D</creatorcontrib><creatorcontrib>JACOBS, M</creatorcontrib><creatorcontrib>SILVA, L</creatorcontrib><creatorcontrib>ABDOU, J. C</creatorcontrib><creatorcontrib>MEIER-KRIESCHE, H. U</creatorcontrib><creatorcontrib>KAPLAN, B</creatorcontrib><creatorcontrib>BONOMINI, L</creatorcontrib><creatorcontrib>DEFRANCO, P</creatorcontrib><creatorcontrib>LYMAN, N</creatorcontrib><creatorcontrib>MULGAONKAR, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRIEDMAN, G. S</au><au>WIK, D</au><au>JACOBS, M</au><au>SILVA, L</au><au>ABDOU, J. C</au><au>MEIER-KRIESCHE, H. U</au><au>KAPLAN, B</au><au>BONOMINI, L</au><au>DEFRANCO, P</au><au>LYMAN, N</au><au>MULGAONKAR, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allograft loss in renal transplant recipients with Fabry's disease and activated protein C resistance</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2000-05-27</date><risdate>2000</risdate><volume>69</volume><issue>10</issue><spage>2099</spage><epage>2102</epage><pages>2099-2102</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Fabry's disease is associated with an increased incidence of thrombotic events and rejection. Spontaneous thrombosis of a functioning cadaveric renal allograft in a recipient with Fabry's disease prompted prospective evaluation of all transplant candidates with Fabry's disease for hypercoagulability.
Transplant candidates with Fabry's disease were tested for hypercoagulability, analyzed for HLA-type and ABO group, and comorbid conditions suggestive of hypercoagulability.
A unique association of Fabry's disease with activated protein C Resistance was documented in a cohort of Caucasian male renal transplant recipients with Fabry's disease. Four of five patients were blood group A and had no significant comorbid conditions suggestive of hypercoagulability. The resistance to activation of protein C (APCR)(+) patients shared HLA loci-B8 and Dr3, although the APCR(-) patients shared HLA loci-B27 and -B38.
Due to the observed increase in the incidence of APCR in our Fabry's cohort, we suggest screening all patients with Fabry's disease for APCR. Because factor V and factor Va receptors are found on vascular endothelium and peripheral blood monocytes, APCR in the presence of Fabry's disease may be a nonimmunological stimulus for rejection. Analysis of HLA typing in patients with Fabry's disease may further elucidate HLA-based association of Fabry's disease and resistance to activated protein C with the risk of thrombosis and rejection.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>10852604</pmid><doi>10.1097/00007890-200005270-00022</doi><tpages>4</tpages></addata></record> |
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| ispartof | Transplantation, 2000-05, Vol.69 (10), p.2099-2102 |
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| subjects | ABO Blood-Group System Activated Protein C Resistance - complications Activated Protein C Resistance - immunology Adult Biological and medical sciences Cohort Studies Comorbidity European Continental Ancestry Group Fabry Disease - complications Fabry Disease - immunology Histocompatibility Testing HLA-B Antigens - analysis HLA-B27 Antigen - analysis HLA-B38 Antigen HLA-B8 Antigen - analysis HLA-DR3 Antigen - analysis Humans Kidney Transplantation - immunology Male Medical sciences Middle Aged protein C Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Transplantation, Homologous Treatment Failure |
| title | Allograft loss in renal transplant recipients with Fabry's disease and activated protein C resistance |
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