Treatment of Erectile Dysfunction in Men With Depressive Symptoms: Results of a Placebo-Controlled Trial With Sildenafil Citrate

OBJECTIVE: Depressed men commonly have erectile dysfunction, and men with erectile dysfunction are frequently depressed. Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized, a 12-week, randomized, double-blind, placebo-controlle...

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Veröffentlicht in:The American journal of psychiatry 2001-10, Vol.158 (10), p.1623-1630
Hauptverfasser: Seidman, Stuart N., Roose, Steven P., Menza, Matthew A., Shabsigh, Ridwan, Rosen, Raymond C.
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container_end_page 1630
container_issue 10
container_start_page 1623
container_title The American journal of psychiatry
container_volume 158
creator Seidman, Stuart N.
Roose, Steven P.
Menza, Matthew A.
Shabsigh, Ridwan
Rosen, Raymond C.
description OBJECTIVE: Depressed men commonly have erectile dysfunction, and men with erectile dysfunction are frequently depressed. Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized, a 12-week, randomized, double-blind, placebo-controlled trial was conducted at 20 urologic clinics to evaluate the effects of sildenafil treatment in men with erectile dysfunction and mild-to-moderate comorbid depressive illness. METHOD: Men (N=152, mean age=56 years) with erectile dysfunction for ≥6 months (mean=5.7 years), a DSM-IV diagnosis of depressive disorder not otherwise specified, and a Hamilton Depression Rating Scale score ≥12 (mean at baseline=16.9) were randomly assigned to flexible-dose treatment with sildenafil citrate or matching placebo. Interviewer-rated and self-report instruments were used to assess changes in sexual function, depressive symptoms, and quality of life. Conservative criteria were used to classify erectile dysfunction treatment response and nonresponse. RESULTS: Sildenafil was strongly associated with erectile dysfunction treatment response. Fifty-eight men met the conservative criteria for response (48 given sildenafil, 10 given placebo), and 78 men did not respond (18 given sildenafil, 60 given placebo). Mean decreases of 10.6 and 2.3 in Hamilton depression scale scores were seen in treatment responders and nonresponders, respectively; 76% of treatment responders showed a ≥50% decline in Hamilton depression scale score versus 14% of nonresponders. Quality of life was similarly improved in treatment responders. CONCLUSIONS: Sildenafil is efficacious for erectile dysfunction in men with mild-to-moderate depressive illness. Improvement of erectile dysfunction is associated with marked improvement in depressive symptoms and quality of life.
doi_str_mv 10.1176/appi.ajp.158.10.1623
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Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized, a 12-week, randomized, double-blind, placebo-controlled trial was conducted at 20 urologic clinics to evaluate the effects of sildenafil treatment in men with erectile dysfunction and mild-to-moderate comorbid depressive illness. METHOD: Men (N=152, mean age=56 years) with erectile dysfunction for ≥6 months (mean=5.7 years), a DSM-IV diagnosis of depressive disorder not otherwise specified, and a Hamilton Depression Rating Scale score ≥12 (mean at baseline=16.9) were randomly assigned to flexible-dose treatment with sildenafil citrate or matching placebo. Interviewer-rated and self-report instruments were used to assess changes in sexual function, depressive symptoms, and quality of life. Conservative criteria were used to classify erectile dysfunction treatment response and nonresponse. RESULTS: Sildenafil was strongly associated with erectile dysfunction treatment response. Fifty-eight men met the conservative criteria for response (48 given sildenafil, 10 given placebo), and 78 men did not respond (18 given sildenafil, 60 given placebo). Mean decreases of 10.6 and 2.3 in Hamilton depression scale scores were seen in treatment responders and nonresponders, respectively; 76% of treatment responders showed a ≥50% decline in Hamilton depression scale score versus 14% of nonresponders. Quality of life was similarly improved in treatment responders. CONCLUSIONS: Sildenafil is efficacious for erectile dysfunction in men with mild-to-moderate depressive illness. Improvement of erectile dysfunction is associated with marked improvement in depressive symptoms and quality of life.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.158.10.1623</identifier><identifier>PMID: 11578994</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>3',5'-Cyclic-GMP Phosphodiesterases - antagonists &amp; inhibitors ; Adult ; Aged ; Biological and medical sciences ; Comorbidity ; Depression ; Depressive Disorder - drug therapy ; Depressive Disorder - epidemiology ; Double blind studies ; Double-Blind Method ; Drug therapy ; Drugs ; Erectile dysfunction ; Erectile Dysfunction - diagnosis ; Erectile Dysfunction - drug therapy ; Erectile Dysfunction - epidemiology ; Hormones. Endocrine system ; Humans ; Male ; Medical sciences ; Men ; Mental depression ; Middle Aged ; Middle aged men ; Personality Inventory - statistics &amp; numerical data ; Pharmacology. Drug treatments ; Phosphodiesterase Inhibitors - therapeutic use ; Piperazines - therapeutic use ; Placebos ; Psychiatric Status Rating Scales - statistics &amp; numerical data ; Purines ; Quality of Life ; Sexual disorders ; Sildenafil Citrate ; Sulfones ; Treatment Outcome</subject><ispartof>The American journal of psychiatry, 2001-10, Vol.158 (10), p.1623-1630</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Oct 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a432t-5f9a93f6b05f1c1fe816fee7df76946850086db775c2b913a71c8915f9b494c53</citedby><cites>FETCH-LOGICAL-a432t-5f9a93f6b05f1c1fe816fee7df76946850086db775c2b913a71c8915f9b494c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.158.10.1623$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.158.10.1623$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27924,27925,31000,77794,77799</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1124926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11578994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seidman, Stuart N.</creatorcontrib><creatorcontrib>Roose, Steven P.</creatorcontrib><creatorcontrib>Menza, Matthew A.</creatorcontrib><creatorcontrib>Shabsigh, Ridwan</creatorcontrib><creatorcontrib>Rosen, Raymond C.</creatorcontrib><title>Treatment of Erectile Dysfunction in Men With Depressive Symptoms: Results of a Placebo-Controlled Trial With Sildenafil Citrate</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Depressed men commonly have erectile dysfunction, and men with erectile dysfunction are frequently depressed. Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized, a 12-week, randomized, double-blind, placebo-controlled trial was conducted at 20 urologic clinics to evaluate the effects of sildenafil treatment in men with erectile dysfunction and mild-to-moderate comorbid depressive illness. METHOD: Men (N=152, mean age=56 years) with erectile dysfunction for ≥6 months (mean=5.7 years), a DSM-IV diagnosis of depressive disorder not otherwise specified, and a Hamilton Depression Rating Scale score ≥12 (mean at baseline=16.9) were randomly assigned to flexible-dose treatment with sildenafil citrate or matching placebo. Interviewer-rated and self-report instruments were used to assess changes in sexual function, depressive symptoms, and quality of life. Conservative criteria were used to classify erectile dysfunction treatment response and nonresponse. RESULTS: Sildenafil was strongly associated with erectile dysfunction treatment response. Fifty-eight men met the conservative criteria for response (48 given sildenafil, 10 given placebo), and 78 men did not respond (18 given sildenafil, 60 given placebo). Mean decreases of 10.6 and 2.3 in Hamilton depression scale scores were seen in treatment responders and nonresponders, respectively; 76% of treatment responders showed a ≥50% decline in Hamilton depression scale score versus 14% of nonresponders. Quality of life was similarly improved in treatment responders. CONCLUSIONS: Sildenafil is efficacious for erectile dysfunction in men with mild-to-moderate depressive illness. 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Drug treatments</topic><topic>Phosphodiesterase Inhibitors - therapeutic use</topic><topic>Piperazines - therapeutic use</topic><topic>Placebos</topic><topic>Psychiatric Status Rating Scales - statistics &amp; numerical data</topic><topic>Purines</topic><topic>Quality of Life</topic><topic>Sexual disorders</topic><topic>Sildenafil Citrate</topic><topic>Sulfones</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seidman, Stuart N.</creatorcontrib><creatorcontrib>Roose, Steven P.</creatorcontrib><creatorcontrib>Menza, Matthew A.</creatorcontrib><creatorcontrib>Shabsigh, Ridwan</creatorcontrib><creatorcontrib>Rosen, Raymond C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Applied Social Sciences Index &amp; Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seidman, Stuart N.</au><au>Roose, Steven P.</au><au>Menza, Matthew A.</au><au>Shabsigh, Ridwan</au><au>Rosen, Raymond C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Erectile Dysfunction in Men With Depressive Symptoms: Results of a Placebo-Controlled Trial With Sildenafil Citrate</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>158</volume><issue>10</issue><spage>1623</spage><epage>1630</epage><pages>1623-1630</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Depressed men commonly have erectile dysfunction, and men with erectile dysfunction are frequently depressed. Since the etiologic and modulatory relationships between depression and erectile dysfunction have been poorly characterized, a 12-week, randomized, double-blind, placebo-controlled trial was conducted at 20 urologic clinics to evaluate the effects of sildenafil treatment in men with erectile dysfunction and mild-to-moderate comorbid depressive illness. METHOD: Men (N=152, mean age=56 years) with erectile dysfunction for ≥6 months (mean=5.7 years), a DSM-IV diagnosis of depressive disorder not otherwise specified, and a Hamilton Depression Rating Scale score ≥12 (mean at baseline=16.9) were randomly assigned to flexible-dose treatment with sildenafil citrate or matching placebo. Interviewer-rated and self-report instruments were used to assess changes in sexual function, depressive symptoms, and quality of life. Conservative criteria were used to classify erectile dysfunction treatment response and nonresponse. RESULTS: Sildenafil was strongly associated with erectile dysfunction treatment response. Fifty-eight men met the conservative criteria for response (48 given sildenafil, 10 given placebo), and 78 men did not respond (18 given sildenafil, 60 given placebo). Mean decreases of 10.6 and 2.3 in Hamilton depression scale scores were seen in treatment responders and nonresponders, respectively; 76% of treatment responders showed a ≥50% decline in Hamilton depression scale score versus 14% of nonresponders. Quality of life was similarly improved in treatment responders. CONCLUSIONS: Sildenafil is efficacious for erectile dysfunction in men with mild-to-moderate depressive illness. Improvement of erectile dysfunction is associated with marked improvement in depressive symptoms and quality of life.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>11578994</pmid><doi>10.1176/appi.ajp.158.10.1623</doi><tpages>8</tpages></addata></record>
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subjects 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors
Adult
Aged
Biological and medical sciences
Comorbidity
Depression
Depressive Disorder - drug therapy
Depressive Disorder - epidemiology
Double blind studies
Double-Blind Method
Drug therapy
Drugs
Erectile dysfunction
Erectile Dysfunction - diagnosis
Erectile Dysfunction - drug therapy
Erectile Dysfunction - epidemiology
Hormones. Endocrine system
Humans
Male
Medical sciences
Men
Mental depression
Middle Aged
Middle aged men
Personality Inventory - statistics & numerical data
Pharmacology. Drug treatments
Phosphodiesterase Inhibitors - therapeutic use
Piperazines - therapeutic use
Placebos
Psychiatric Status Rating Scales - statistics & numerical data
Purines
Quality of Life
Sexual disorders
Sildenafil Citrate
Sulfones
Treatment Outcome
title Treatment of Erectile Dysfunction in Men With Depressive Symptoms: Results of a Placebo-Controlled Trial With Sildenafil Citrate
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