Manganese deposition in the globus pallidus in patients with biliary atresia
Chronic liver diseases may alter trace element contents in the brain. Among these trace elements, manganese is a ubiquitous transition metal excreted by the liver into the bile. Blood concentrations of manganese are elevated in patients with biliary atresia who have undergone hepatic portoenterostom...
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| Veröffentlicht in: | Transplantation 2000-06, Vol.69 (11), p.2339-2343 |
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| creator | IKEDA, S YAMAGUCHI, Y SERA, Y OHSHIRO, H UCHINO, S YAMASHITA, Y OGAWA, M |
| description | Chronic liver diseases may alter trace element contents in the brain. Among these trace elements, manganese is a ubiquitous transition metal excreted by the liver into the bile. Blood concentrations of manganese are elevated in patients with biliary atresia who have undergone hepatic portoenterostomy. The present study investigated the effects of liver transplantation on manganese deposition in the brain in such patients.
The signal intensity of the globus pallidus was calculated as an index defined as the percentile ratio of signal intensity in the globus pallidus to the subcortical frontal white-matter in sagittal T1-weighted magnetic resonance imaging planes.
Brain magnetic resonance imaging revealed hyperintense signals in the globus pallidus due to manganese deposition in biliary atresia patients. Few neurologic symptoms related to manganese intoxication were observed. However, one 23-year-old female with biliary atresia had depressive symptoms and dyskinesia; she improved after oral administration of the dopamine precursor, L-DOPA. Manganese deposition disappeared in two patients after living-related reduced-size hepatic transplantation.
Manganese accumulates in the brain during cholestasis associated with biliary atresia and disappears after hepatic transplantation. Manganese deposition is likely to be subclinical and reversible but may be associated with some age-related neurologic symptoms. |
| doi_str_mv | 10.1097/00007890-200006150-00021 |
| format | Article |
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The signal intensity of the globus pallidus was calculated as an index defined as the percentile ratio of signal intensity in the globus pallidus to the subcortical frontal white-matter in sagittal T1-weighted magnetic resonance imaging planes.
Brain magnetic resonance imaging revealed hyperintense signals in the globus pallidus due to manganese deposition in biliary atresia patients. Few neurologic symptoms related to manganese intoxication were observed. However, one 23-year-old female with biliary atresia had depressive symptoms and dyskinesia; she improved after oral administration of the dopamine precursor, L-DOPA. Manganese deposition disappeared in two patients after living-related reduced-size hepatic transplantation.
Manganese accumulates in the brain during cholestasis associated with biliary atresia and disappears after hepatic transplantation. Manganese deposition is likely to be subclinical and reversible but may be associated with some age-related neurologic symptoms.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-200006150-00021</identifier><identifier>PMID: 10868637</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Biliary Atresia - blood ; Biliary Atresia - diagnosis ; Biliary Atresia - metabolism ; Biliary Atresia - surgery ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Globus Pallidus - metabolism ; Globus Pallidus - pathology ; Humans ; Infant ; Liver Transplantation ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Living Donors ; Magnetic Resonance Imaging ; Male ; Malformations ; manganese ; Manganese - blood ; Manganese - metabolism ; Medical sciences ; Postoperative Period ; Reference Values ; Regression Analysis</subject><ispartof>Transplantation, 2000-06, Vol.69 (11), p.2339-2343</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-6c7120b6b3fbc83243a1800988a5eab081573cb159e6fce697544d05458e4a123</citedby><cites>FETCH-LOGICAL-c421t-6c7120b6b3fbc83243a1800988a5eab081573cb159e6fce697544d05458e4a123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1484299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10868637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IKEDA, S</creatorcontrib><creatorcontrib>YAMAGUCHI, Y</creatorcontrib><creatorcontrib>SERA, Y</creatorcontrib><creatorcontrib>OHSHIRO, H</creatorcontrib><creatorcontrib>UCHINO, S</creatorcontrib><creatorcontrib>YAMASHITA, Y</creatorcontrib><creatorcontrib>OGAWA, M</creatorcontrib><title>Manganese deposition in the globus pallidus in patients with biliary atresia</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Chronic liver diseases may alter trace element contents in the brain. Among these trace elements, manganese is a ubiquitous transition metal excreted by the liver into the bile. Blood concentrations of manganese are elevated in patients with biliary atresia who have undergone hepatic portoenterostomy. The present study investigated the effects of liver transplantation on manganese deposition in the brain in such patients.
The signal intensity of the globus pallidus was calculated as an index defined as the percentile ratio of signal intensity in the globus pallidus to the subcortical frontal white-matter in sagittal T1-weighted magnetic resonance imaging planes.
Brain magnetic resonance imaging revealed hyperintense signals in the globus pallidus due to manganese deposition in biliary atresia patients. Few neurologic symptoms related to manganese intoxication were observed. However, one 23-year-old female with biliary atresia had depressive symptoms and dyskinesia; she improved after oral administration of the dopamine precursor, L-DOPA. Manganese deposition disappeared in two patients after living-related reduced-size hepatic transplantation.
Manganese accumulates in the brain during cholestasis associated with biliary atresia and disappears after hepatic transplantation. Manganese deposition is likely to be subclinical and reversible but may be associated with some age-related neurologic symptoms.</description><subject>Adult</subject><subject>Biliary Atresia - blood</subject><subject>Biliary Atresia - diagnosis</subject><subject>Biliary Atresia - metabolism</subject><subject>Biliary Atresia - surgery</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Globus Pallidus - metabolism</subject><subject>Globus Pallidus - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Liver Transplantation</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Living Donors</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Malformations</subject><subject>manganese</subject><subject>Manganese - blood</subject><subject>Manganese - metabolism</subject><subject>Medical sciences</subject><subject>Postoperative Period</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAMgCMEYmPwF1AOiFvBbpImOSLESxriAucqzdItKGtL0wrx78nYeNzwxZb12ZY_QijCBYKWl5BCKg1ZvqkKFJClnOMemaJgPCtAwT6ZAnDMkDE5IUcxviZEMCkPyQRBFapgckrmj6ZZmsZFRxeua6MffNtQ39Bh5egytNUYaWdC8ItUpHZnBu-aIdJ3P6xo5YM3_Qc1Q--iN8fkoDYhupNdnpGX25vn6_ts_nT3cH01zyzPccgKKzGHqqhYXVnFcs4MKgCtlBHOVKBQSGYrFNoVtXWFloLzBQgulOMGczYj59u9Xd--jS4O5dpH60JIj7RjLDfrOTLxL4gyudPAEqi2oO3bGHtXl13v1-m1EqHcKC-_lZc_yssv5Wn0dHdjrNZu8Wdw6zgBZzvARGtC3ZvG-vjLccVzrdknvhWHsQ</recordid><startdate>20000615</startdate><enddate>20000615</enddate><creator>IKEDA, S</creator><creator>YAMAGUCHI, Y</creator><creator>SERA, Y</creator><creator>OHSHIRO, H</creator><creator>UCHINO, S</creator><creator>YAMASHITA, Y</creator><creator>OGAWA, M</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000615</creationdate><title>Manganese deposition in the globus pallidus in patients with biliary atresia</title><author>IKEDA, S ; YAMAGUCHI, Y ; SERA, Y ; OHSHIRO, H ; UCHINO, S ; YAMASHITA, Y ; OGAWA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6c7120b6b3fbc83243a1800988a5eab081573cb159e6fce697544d05458e4a123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biliary Atresia - blood</topic><topic>Biliary Atresia - diagnosis</topic><topic>Biliary Atresia - metabolism</topic><topic>Biliary Atresia - surgery</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Globus Pallidus - metabolism</topic><topic>Globus Pallidus - pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Liver Transplantation</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Living Donors</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Malformations</topic><topic>manganese</topic><topic>Manganese - blood</topic><topic>Manganese - metabolism</topic><topic>Medical sciences</topic><topic>Postoperative Period</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IKEDA, S</creatorcontrib><creatorcontrib>YAMAGUCHI, Y</creatorcontrib><creatorcontrib>SERA, Y</creatorcontrib><creatorcontrib>OHSHIRO, H</creatorcontrib><creatorcontrib>UCHINO, S</creatorcontrib><creatorcontrib>YAMASHITA, Y</creatorcontrib><creatorcontrib>OGAWA, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKEDA, S</au><au>YAMAGUCHI, Y</au><au>SERA, Y</au><au>OHSHIRO, H</au><au>UCHINO, S</au><au>YAMASHITA, Y</au><au>OGAWA, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manganese deposition in the globus pallidus in patients with biliary atresia</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2000-06-15</date><risdate>2000</risdate><volume>69</volume><issue>11</issue><spage>2339</spage><epage>2343</epage><pages>2339-2343</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Chronic liver diseases may alter trace element contents in the brain. Among these trace elements, manganese is a ubiquitous transition metal excreted by the liver into the bile. Blood concentrations of manganese are elevated in patients with biliary atresia who have undergone hepatic portoenterostomy. The present study investigated the effects of liver transplantation on manganese deposition in the brain in such patients.
The signal intensity of the globus pallidus was calculated as an index defined as the percentile ratio of signal intensity in the globus pallidus to the subcortical frontal white-matter in sagittal T1-weighted magnetic resonance imaging planes.
Brain magnetic resonance imaging revealed hyperintense signals in the globus pallidus due to manganese deposition in biliary atresia patients. Few neurologic symptoms related to manganese intoxication were observed. However, one 23-year-old female with biliary atresia had depressive symptoms and dyskinesia; she improved after oral administration of the dopamine precursor, L-DOPA. Manganese deposition disappeared in two patients after living-related reduced-size hepatic transplantation.
Manganese accumulates in the brain during cholestasis associated with biliary atresia and disappears after hepatic transplantation. Manganese deposition is likely to be subclinical and reversible but may be associated with some age-related neurologic symptoms.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>10868637</pmid><doi>10.1097/00007890-200006150-00021</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biliary Atresia - blood Biliary Atresia - diagnosis Biliary Atresia - metabolism Biliary Atresia - surgery Biological and medical sciences Child Child, Preschool Female Gastroenterology. Liver. Pancreas. Abdomen Globus Pallidus - metabolism Globus Pallidus - pathology Humans Infant Liver Transplantation Liver. Biliary tract. Portal circulation. Exocrine pancreas Living Donors Magnetic Resonance Imaging Male Malformations manganese Manganese - blood Manganese - metabolism Medical sciences Postoperative Period Reference Values Regression Analysis |
| title | Manganese deposition in the globus pallidus in patients with biliary atresia |
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