Study of Synthesis and Cardiovascular Activity of Some Furoxan Derivatives as Potential NO-Donors

A series of hydrid molecules incorporating the furoxan and nicorandil moieties were designed as potential NO donors with cardiovascular and cerebrovascular activities. Thirty-six target molecules were successfully synthesized by conventional methods and characterized by infrared spactroscopy, 1H-NMR...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2000/06/01, Vol.48(6), pp.808-816
Hauptverfasser:	MU, Li, FENG, Si-shen, GO, Mei Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Biological and medical sciences Cardiovascular system Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Female furoxan derivatives hypertension In Vitro Techniques Male Medical sciences Muscle Contraction nitric oxide Nitric Oxide Donors - chemical synthesis Nitric Oxide Donors - chemistry Nitric Oxide Donors - pharmacology NO-donor Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - pharmacology Pharmacology. Drug treatments Rabbits Spectrum Analysis Structure-Activity Relationship synthesis vasodilation
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