Discovery and mapping of ten novel G protein-coupled receptor genes
We report the identification, cloning and tissue distributions of ten novel human genes encoding G protein-coupled receptors (GPCRs) GPR78, GPR80, GPR81, GPR82, GPR93, GPR94, GPR95, GPR101, GPR102, GPR103 and a pseudogene, ψGPR79. Each novel orphan GPCR (oGPCR) gene was discovered using customized s...
Gespeichert in:
| Veröffentlicht in: | Gene 2001-09, Vol.275 (1), p.83-91 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 91 |
|---|---|
| container_issue | 1 |
| container_start_page | 83 |
| container_title | Gene |
| container_volume | 275 |
| creator | Lee, Dennis K. Nguyen, Tuan Lynch, Kevin R. Cheng, Regina Vanti, William B. Arkhitko, Oxana Lewis, Tressa Evans, Jilly F. George, Susan R. O'Dowd, Brian F. |
| description | We report the identification, cloning and tissue distributions of ten novel human genes encoding G protein-coupled receptors (GPCRs)
GPR78,
GPR80,
GPR81,
GPR82,
GPR93,
GPR94,
GPR95,
GPR101,
GPR102,
GPR103 and a pseudogene,
ψGPR79. Each novel orphan GPCR (oGPCR) gene was discovered using customized searches of the GenBank high-throughput genomic sequences database with previously known GPCR-encoding sequences. The expressed genes can now be used in assays to determine endogenous and pharmacological ligands.
GPR78 shared highest identity with the oGPCR gene
GPR26 (56% identity in the transmembrane (TM) regions).
ψGPR79 shared highest sequence identity with the
P2Y
2
gene and contained a frame-shift truncating the encoded receptor in TM5, demonstrating a pseudogene.
GPR80 shared highest identity with the
P2Y
1
gene (45% in the TM regions), while
GPR81,
GPR82 and
GPR93 shared TM identities with the oGPCR genes
HM74 (70%),
GPR17 (30%) and
P2Y
5
(40%), respectively. Two other novel GPCR genes,
GPR94 and
GPR95, encoded a subfamily with the genes encoding the UDP-glucose and P2Y
12 receptors (sharing >50% identities in the TM regions).
GPR101 demonstrated only distant identities with other GPCR genes and
GPR102 shared identities with
GPR57,
GPR58 and
PNR (35–42% in the TM regions).
GPR103 shared identities with the neuropeptide FF 2, neuropeptide Y2 and galanin GalR1 receptors (34–38% in the TM regions). Northern analyses revealed
GPR78 mRNA expression in the pituitary and placenta and
GPR81 expression in the pituitary. A search of the GenBank databases with the
GPR82 sequence retrieved an identical sequence in an expressed sequence tag (EST) partially encoding
GPR82 from human colonic tissue. The
GPR93 sequence retrieved an identical, human EST sequence from human primary tonsil B-cells and an EST partially encoding mouse
GPR93 from small intestinal tissue.
GPR94 was expressed in the frontal cortex, caudate putamen and thalamus of brain while
GPR95 was expressed in the human prostate and rat stomach and fetal tissues.
GPR101 revealed mRNA transcripts in caudate putamen and hypothalamus.
GPR103 mRNA signals were detected in the cortex, pituitary, thalamus, hypothalamus, basal forebrain, midbrain and pons. |
| doi_str_mv | 10.1016/S0378-1119(01)00651-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71203886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378111901006515</els_id><sourcerecordid>71203886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-237534efe9992c58de83f20611ffc606e85f7dc27ac8f83ad025ebc6b873574d3</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqXwE0CeEAwBX1LHzoRQgYJUiQGYrdQ-V0FpHOykUv897odgrJcb_Nzdew8hl8DugEF-_8EyIRMAKG4Y3DKWc0j4ERmCFEXCWCaPyfAPGZCzEL5ZfJynp2QAwMUYOB-SyVMVtFuhX9OyMXRZtm3VLKiztMOGNvGnplPaetdh1STa9W2NhnrU2HbO0wU2GM7JiS3rgBf7OiJfL8-fk9dk9j59mzzOEs2BdUmaCZ6N0WJRFKnm0qDMbMpyAGt1znKU3AqjU1FqaWVWGpZynOt8LkUW45psRK53c2Ocnx5Dp5YxPNZ12aDrgxKQxrtlfhAEUQBLxTiCfAdq70LwaFXrq2Xp1wqY2mhWW81q41AxUFvNise-q_2Cfr5E89-19xqBhx2A0ceqQq-CrrDRaKrorlPGVQdW_AKAOIuk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17910274</pqid></control><display><type>article</type><title>Discovery and mapping of ten novel G protein-coupled receptor genes</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Lee, Dennis K. ; Nguyen, Tuan ; Lynch, Kevin R. ; Cheng, Regina ; Vanti, William B. ; Arkhitko, Oxana ; Lewis, Tressa ; Evans, Jilly F. ; George, Susan R. ; O'Dowd, Brian F.</creator><creatorcontrib>Lee, Dennis K. ; Nguyen, Tuan ; Lynch, Kevin R. ; Cheng, Regina ; Vanti, William B. ; Arkhitko, Oxana ; Lewis, Tressa ; Evans, Jilly F. ; George, Susan R. ; O'Dowd, Brian F.</creatorcontrib><description>We report the identification, cloning and tissue distributions of ten novel human genes encoding G protein-coupled receptors (GPCRs)
GPR78,
GPR80,
GPR81,
GPR82,
GPR93,
GPR94,
GPR95,
GPR101,
GPR102,
GPR103 and a pseudogene,
ψGPR79. Each novel orphan GPCR (oGPCR) gene was discovered using customized searches of the GenBank high-throughput genomic sequences database with previously known GPCR-encoding sequences. The expressed genes can now be used in assays to determine endogenous and pharmacological ligands.
GPR78 shared highest identity with the oGPCR gene
GPR26 (56% identity in the transmembrane (TM) regions).
ψGPR79 shared highest sequence identity with the
P2Y
2
gene and contained a frame-shift truncating the encoded receptor in TM5, demonstrating a pseudogene.
GPR80 shared highest identity with the
P2Y
1
gene (45% in the TM regions), while
GPR81,
GPR82 and
GPR93 shared TM identities with the oGPCR genes
HM74 (70%),
GPR17 (30%) and
P2Y
5
(40%), respectively. Two other novel GPCR genes,
GPR94 and
GPR95, encoded a subfamily with the genes encoding the UDP-glucose and P2Y
12 receptors (sharing >50% identities in the TM regions).
GPR101 demonstrated only distant identities with other GPCR genes and
GPR102 shared identities with
GPR57,
GPR58 and
PNR (35–42% in the TM regions).
GPR103 shared identities with the neuropeptide FF 2, neuropeptide Y2 and galanin GalR1 receptors (34–38% in the TM regions). Northern analyses revealed
GPR78 mRNA expression in the pituitary and placenta and
GPR81 expression in the pituitary. A search of the GenBank databases with the
GPR82 sequence retrieved an identical sequence in an expressed sequence tag (EST) partially encoding
GPR82 from human colonic tissue. The
GPR93 sequence retrieved an identical, human EST sequence from human primary tonsil B-cells and an EST partially encoding mouse
GPR93 from small intestinal tissue.
GPR94 was expressed in the frontal cortex, caudate putamen and thalamus of brain while
GPR95 was expressed in the human prostate and rat stomach and fetal tissues.
GPR101 revealed mRNA transcripts in caudate putamen and hypothalamus.
GPR103 mRNA signals were detected in the cortex, pituitary, thalamus, hypothalamus, basal forebrain, midbrain and pons.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/S0378-1119(01)00651-5</identifier><identifier>PMID: 11574155</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Chromosome ; Chromosome Mapping ; Cloning, Molecular ; DNA - chemistry ; DNA - genetics ; DNA, Complementary - chemistry ; DNA, Complementary - genetics ; Female ; Gene Expression ; GPR101 gene ; GPR102 gene ; GPR103 gene ; GPR78 gene ; GPR80 gene ; GPR81 gene ; GPR82 gene ; GPR93 gene ; GPR94 gene ; GPR95 gene ; GTP-Binding Proteins - metabolism ; Humans ; Intronless ; Male ; Molecular Sequence Data ; Orphan G protein-coupled receptor ; P2Y gene ; Pseudogene ; Pseudogenes - genetics ; qGPR79 gene ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Tissue Distribution ; Transmembrane ; UDP-glucose receptors</subject><ispartof>Gene, 2001-09, Vol.275 (1), p.83-91</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-237534efe9992c58de83f20611ffc606e85f7dc27ac8f83ad025ebc6b873574d3</citedby><cites>FETCH-LOGICAL-c510t-237534efe9992c58de83f20611ffc606e85f7dc27ac8f83ad025ebc6b873574d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-1119(01)00651-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11574155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dennis K.</creatorcontrib><creatorcontrib>Nguyen, Tuan</creatorcontrib><creatorcontrib>Lynch, Kevin R.</creatorcontrib><creatorcontrib>Cheng, Regina</creatorcontrib><creatorcontrib>Vanti, William B.</creatorcontrib><creatorcontrib>Arkhitko, Oxana</creatorcontrib><creatorcontrib>Lewis, Tressa</creatorcontrib><creatorcontrib>Evans, Jilly F.</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><creatorcontrib>O'Dowd, Brian F.</creatorcontrib><title>Discovery and mapping of ten novel G protein-coupled receptor genes</title><title>Gene</title><addtitle>Gene</addtitle><description>We report the identification, cloning and tissue distributions of ten novel human genes encoding G protein-coupled receptors (GPCRs)
GPR78,
GPR80,
GPR81,
GPR82,
GPR93,
GPR94,
GPR95,
GPR101,
GPR102,
GPR103 and a pseudogene,
ψGPR79. Each novel orphan GPCR (oGPCR) gene was discovered using customized searches of the GenBank high-throughput genomic sequences database with previously known GPCR-encoding sequences. The expressed genes can now be used in assays to determine endogenous and pharmacological ligands.
GPR78 shared highest identity with the oGPCR gene
GPR26 (56% identity in the transmembrane (TM) regions).
ψGPR79 shared highest sequence identity with the
P2Y
2
gene and contained a frame-shift truncating the encoded receptor in TM5, demonstrating a pseudogene.
GPR80 shared highest identity with the
P2Y
1
gene (45% in the TM regions), while
GPR81,
GPR82 and
GPR93 shared TM identities with the oGPCR genes
HM74 (70%),
GPR17 (30%) and
P2Y
5
(40%), respectively. Two other novel GPCR genes,
GPR94 and
GPR95, encoded a subfamily with the genes encoding the UDP-glucose and P2Y
12 receptors (sharing >50% identities in the TM regions).
GPR101 demonstrated only distant identities with other GPCR genes and
GPR102 shared identities with
GPR57,
GPR58 and
PNR (35–42% in the TM regions).
GPR103 shared identities with the neuropeptide FF 2, neuropeptide Y2 and galanin GalR1 receptors (34–38% in the TM regions). Northern analyses revealed
GPR78 mRNA expression in the pituitary and placenta and
GPR81 expression in the pituitary. A search of the GenBank databases with the
GPR82 sequence retrieved an identical sequence in an expressed sequence tag (EST) partially encoding
GPR82 from human colonic tissue. The
GPR93 sequence retrieved an identical, human EST sequence from human primary tonsil B-cells and an EST partially encoding mouse
GPR93 from small intestinal tissue.
GPR94 was expressed in the frontal cortex, caudate putamen and thalamus of brain while
GPR95 was expressed in the human prostate and rat stomach and fetal tissues.
GPR101 revealed mRNA transcripts in caudate putamen and hypothalamus.
GPR103 mRNA signals were detected in the cortex, pituitary, thalamus, hypothalamus, basal forebrain, midbrain and pons.</description><subject>Amino Acid Sequence</subject><subject>Chromosome</subject><subject>Chromosome Mapping</subject><subject>Cloning, Molecular</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>DNA, Complementary - chemistry</subject><subject>DNA, Complementary - genetics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>GPR101 gene</subject><subject>GPR102 gene</subject><subject>GPR103 gene</subject><subject>GPR78 gene</subject><subject>GPR80 gene</subject><subject>GPR81 gene</subject><subject>GPR82 gene</subject><subject>GPR93 gene</subject><subject>GPR94 gene</subject><subject>GPR95 gene</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Intronless</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Orphan G protein-coupled receptor</subject><subject>P2Y gene</subject><subject>Pseudogene</subject><subject>Pseudogenes - genetics</subject><subject>qGPR79 gene</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tissue Distribution</subject><subject>Transmembrane</subject><subject>UDP-glucose receptors</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwE0CeEAwBX1LHzoRQgYJUiQGYrdQ-V0FpHOykUv897odgrJcb_Nzdew8hl8DugEF-_8EyIRMAKG4Y3DKWc0j4ERmCFEXCWCaPyfAPGZCzEL5ZfJynp2QAwMUYOB-SyVMVtFuhX9OyMXRZtm3VLKiztMOGNvGnplPaetdh1STa9W2NhnrU2HbO0wU2GM7JiS3rgBf7OiJfL8-fk9dk9j59mzzOEs2BdUmaCZ6N0WJRFKnm0qDMbMpyAGt1znKU3AqjU1FqaWVWGpZynOt8LkUW45psRK53c2Ocnx5Dp5YxPNZ12aDrgxKQxrtlfhAEUQBLxTiCfAdq70LwaFXrq2Xp1wqY2mhWW81q41AxUFvNise-q_2Cfr5E89-19xqBhx2A0ceqQq-CrrDRaKrorlPGVQdW_AKAOIuk</recordid><startdate>20010905</startdate><enddate>20010905</enddate><creator>Lee, Dennis K.</creator><creator>Nguyen, Tuan</creator><creator>Lynch, Kevin R.</creator><creator>Cheng, Regina</creator><creator>Vanti, William B.</creator><creator>Arkhitko, Oxana</creator><creator>Lewis, Tressa</creator><creator>Evans, Jilly F.</creator><creator>George, Susan R.</creator><creator>O'Dowd, Brian F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010905</creationdate><title>Discovery and mapping of ten novel G protein-coupled receptor genes</title><author>Lee, Dennis K. ; Nguyen, Tuan ; Lynch, Kevin R. ; Cheng, Regina ; Vanti, William B. ; Arkhitko, Oxana ; Lewis, Tressa ; Evans, Jilly F. ; George, Susan R. ; O'Dowd, Brian F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-237534efe9992c58de83f20611ffc606e85f7dc27ac8f83ad025ebc6b873574d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Chromosome</topic><topic>Chromosome Mapping</topic><topic>Cloning, Molecular</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>DNA, Complementary - chemistry</topic><topic>DNA, Complementary - genetics</topic><topic>Female</topic><topic>Gene Expression</topic><topic>GPR101 gene</topic><topic>GPR102 gene</topic><topic>GPR103 gene</topic><topic>GPR78 gene</topic><topic>GPR80 gene</topic><topic>GPR81 gene</topic><topic>GPR82 gene</topic><topic>GPR93 gene</topic><topic>GPR94 gene</topic><topic>GPR95 gene</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>Intronless</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Orphan G protein-coupled receptor</topic><topic>P2Y gene</topic><topic>Pseudogene</topic><topic>Pseudogenes - genetics</topic><topic>qGPR79 gene</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tissue Distribution</topic><topic>Transmembrane</topic><topic>UDP-glucose receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Dennis K.</creatorcontrib><creatorcontrib>Nguyen, Tuan</creatorcontrib><creatorcontrib>Lynch, Kevin R.</creatorcontrib><creatorcontrib>Cheng, Regina</creatorcontrib><creatorcontrib>Vanti, William B.</creatorcontrib><creatorcontrib>Arkhitko, Oxana</creatorcontrib><creatorcontrib>Lewis, Tressa</creatorcontrib><creatorcontrib>Evans, Jilly F.</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><creatorcontrib>O'Dowd, Brian F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dennis K.</au><au>Nguyen, Tuan</au><au>Lynch, Kevin R.</au><au>Cheng, Regina</au><au>Vanti, William B.</au><au>Arkhitko, Oxana</au><au>Lewis, Tressa</au><au>Evans, Jilly F.</au><au>George, Susan R.</au><au>O'Dowd, Brian F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery and mapping of ten novel G protein-coupled receptor genes</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2001-09-05</date><risdate>2001</risdate><volume>275</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>We report the identification, cloning and tissue distributions of ten novel human genes encoding G protein-coupled receptors (GPCRs)
GPR78,
GPR80,
GPR81,
GPR82,
GPR93,
GPR94,
GPR95,
GPR101,
GPR102,
GPR103 and a pseudogene,
ψGPR79. Each novel orphan GPCR (oGPCR) gene was discovered using customized searches of the GenBank high-throughput genomic sequences database with previously known GPCR-encoding sequences. The expressed genes can now be used in assays to determine endogenous and pharmacological ligands.
GPR78 shared highest identity with the oGPCR gene
GPR26 (56% identity in the transmembrane (TM) regions).
ψGPR79 shared highest sequence identity with the
P2Y
2
gene and contained a frame-shift truncating the encoded receptor in TM5, demonstrating a pseudogene.
GPR80 shared highest identity with the
P2Y
1
gene (45% in the TM regions), while
GPR81,
GPR82 and
GPR93 shared TM identities with the oGPCR genes
HM74 (70%),
GPR17 (30%) and
P2Y
5
(40%), respectively. Two other novel GPCR genes,
GPR94 and
GPR95, encoded a subfamily with the genes encoding the UDP-glucose and P2Y
12 receptors (sharing >50% identities in the TM regions).
GPR101 demonstrated only distant identities with other GPCR genes and
GPR102 shared identities with
GPR57,
GPR58 and
PNR (35–42% in the TM regions).
GPR103 shared identities with the neuropeptide FF 2, neuropeptide Y2 and galanin GalR1 receptors (34–38% in the TM regions). Northern analyses revealed
GPR78 mRNA expression in the pituitary and placenta and
GPR81 expression in the pituitary. A search of the GenBank databases with the
GPR82 sequence retrieved an identical sequence in an expressed sequence tag (EST) partially encoding
GPR82 from human colonic tissue. The
GPR93 sequence retrieved an identical, human EST sequence from human primary tonsil B-cells and an EST partially encoding mouse
GPR93 from small intestinal tissue.
GPR94 was expressed in the frontal cortex, caudate putamen and thalamus of brain while
GPR95 was expressed in the human prostate and rat stomach and fetal tissues.
GPR101 revealed mRNA transcripts in caudate putamen and hypothalamus.
GPR103 mRNA signals were detected in the cortex, pituitary, thalamus, hypothalamus, basal forebrain, midbrain and pons.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11574155</pmid><doi>10.1016/S0378-1119(01)00651-5</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1119 |
| ispartof | Gene, 2001-09, Vol.275 (1), p.83-91 |
| issn | 0378-1119 1879-0038 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71203886 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Chromosome Chromosome Mapping Cloning, Molecular DNA - chemistry DNA - genetics DNA, Complementary - chemistry DNA, Complementary - genetics Female Gene Expression GPR101 gene GPR102 gene GPR103 gene GPR78 gene GPR80 gene GPR81 gene GPR82 gene GPR93 gene GPR94 gene GPR95 gene GTP-Binding Proteins - metabolism Humans Intronless Male Molecular Sequence Data Orphan G protein-coupled receptor P2Y gene Pseudogene Pseudogenes - genetics qGPR79 gene Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Tissue Distribution Transmembrane UDP-glucose receptors |
| title | Discovery and mapping of ten novel G protein-coupled receptor genes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T17%3A58%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20and%20mapping%20of%20ten%20novel%20G%20protein-coupled%20receptor%20genes&rft.jtitle=Gene&rft.au=Lee,%20Dennis%20K.&rft.date=2001-09-05&rft.volume=275&rft.issue=1&rft.spage=83&rft.epage=91&rft.pages=83-91&rft.issn=0378-1119&rft.eissn=1879-0038&rft_id=info:doi/10.1016/S0378-1119(01)00651-5&rft_dat=%3Cproquest_cross%3E71203886%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17910274&rft_id=info:pmid/11574155&rft_els_id=S0378111901006515&rfr_iscdi=true |