Induction of Apoptosis in the Human Promyelocytic Leukemia Cell Line HL60 by Falconensone A and Its Derivatives, New Polyenes

Falconensones A and B are a new type of yellow pigment with structural similarity to retinoic acid isolated from the mycelial extract of ascomycetous fungi, Emericella falconensis or Emericella fruticulosa. In the present study we show that falconensone A alone induced apoptosis of HL60 human leukem...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/06/01, Vol.23(6), pp.748-754
Hauptverfasser:	TAKAHASHI, Noriko, KUBO, Yoshinori, IWAHORI, Akiyo, KAWAI, Ken-ichi, FUKUI, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Apoptosis - drug effects Biological and medical sciences Cyclopentanes - chemistry Cyclopentanes - pharmacology Electrophoresis, Agar Gel falconensone General pharmacology HL-60 Cells HL60 cell Humans In Situ Nick-End Labeling Ketones - chemistry Ketones - pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments polyene Polyenes - chemistry Polyenes - pharmacology Reactive Oxygen Species retinoid
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