Interferon-induced rat Mx proteins confer resistance to Rift Valley fever virus and other arthropod-borne viruses

Mx proteins belong to the interferon (IFN)-induced antiviral defense. The rat genome contains three Mx genes, ratMx1, ratMx2, and ratMx3. The Mx gene products differ in their subcellular localization and antiviral specificity. The nuclear ratMx1 protein confers resistance to influenza A virus, and t...

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Veröffentlicht in:	Journal of interferon & cytokine research 2001-09, Vol.21 (9), p.663-668
Hauptverfasser:	Sandrock, M, Frese, M, Haller, O, Kochs, G
Format:	Artikel
Sprache:	eng
Schlagworte:	AMx protein Animals Arboviruses - drug effects Cercopithecus aethiops GTP-Binding Proteins Influenza A virus Influenza A virus - drug effects Interferons - metabolism La Crosse virus La Crosse virus - drug effects Mx protein Mx1 gene Mx2 gene Mx3 gene Myxovirus Resistance Proteins Proteins - metabolism Proteins - pharmacology Rats Rift Valley fever virus Rift Valley fever virus - drug effects Subcellular Fractions - metabolism Thogoto virus Thogotovirus - drug effects Transfection Vero Cells - metabolism Vesicular stomatitis Indiana virus - drug effects Virus Replication - drug effects
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