Fibrillar Amyloid β-Protein Binds Protease Nexin-2/Amyloid β-Protein Precursor:  Stimulation of Its Inhibition of Coagulation Factor XIa

Cerebrovascular deposition of fibrillar 39−42 amino acid amyloid β-protein (Aβ), a condition known as cerebral amyloid angiopathy (CAA), is a key pathological feature of Alzheimer's disease and related disorders including hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). Sev...

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Veröffentlicht in:	Biochemistry (Easton) 2000-06, Vol.39 (25), p.7420-7427
Hauptverfasser:	Wagner, Matthew R, Keane, David M, Melchor, Jerry P, Auspaker, Kenneth R, Van Nostrand, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Base Sequence Carrier Proteins - metabolism DNA Primers Factor XIa - antagonists & inhibitors Humans protease nexin-2 Protease Nexins Receptors, Cell Surface
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