Liquid Chromatography–Mass Spectrometry and Proton Nuclear Magnetic Resonance Characterization of Trace Level Condensation Products Formed Between Lactose and the Amine‐Containing Diuretic Hydrochlorothiazide

Trace levels of condensation products between lactose and the amine‐containing diuretic hydrochlorothiazide are formed when a mixture of the two solids containing 30% weight water is heated at 60 °C for 2 weeks. The two most abundant condensation products were characterized by liquid chromatography‐...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2000-07, Vol.89 (7), p.920-929
Hauptverfasser:	Harmon, Paul A., Yin, Winnie, Bowen, William E., Tyrrell, R.J., Reed, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	amine-lactose reactions Biological and medical sciences Chemical Phenomena Chemistry, Physical Chromatography, High Pressure Liquid Diuretics glycosylamines (formation of) Hydrochlorothiazide - chemistry Hydrolysis Indicators and Reagents Lactose - chemistry Magnetic Resonance Spectroscopy Maillard reactions Mass Spectrometry Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sodium Chloride Symporter Inhibitors - chemistry Solubility Spectrophotometry, Ultraviolet
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