Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents
Metoclopramide may be used to stimulate gastric emptying when anaesthetizing children for emergency operations. Unfortunately, metoclopramide is associated with extrapyramidal side effects. Erythromycin, a motilin receptor agonist, is a prokinetic agent but its use has been little investigated in ch...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2001-06, Vol.86 (6), p.869-871 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | Zatman, T.F. Hall, J.E. Harmer, M. |
| description | Metoclopramide may be used to stimulate gastric emptying when anaesthetizing children for emergency operations. Unfortunately, metoclopramide is associated with extrapyramidal side effects. Erythromycin, a motilin receptor agonist, is a prokinetic agent but its use has been little investigated in children. This randomized double-blind study compared the effects of premedication with oral metoclopramide 0.15 mg kg–1 or erythromycin 1 mg kg–1 on gastric emptying in 80 children undergoing tonsillectomy. Pre-operative fluids, premedication and anaesthetic technique were standardized and gastric volume was measured with an orogastric tube. Post-operative nausea and vomiting was recorded. Metoclopramide and erythromycin produced similar gastric volumes (0.29 and 0.24 ml kg–1) and there was no difference in post-operative vomiting. In the erythromycin group there were more patients with negative aspirates (45.9%) than in the metoclopramide group (35.1%), but the difference was not statistically significant. These results indicate that erythromycin may be as effective as metoclopramide as a prokinetic agent. |
| doi_str_mv | 10.1093/bja/86.6.869 |
| format | Article |
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Unfortunately, metoclopramide is associated with extrapyramidal side effects. Erythromycin, a motilin receptor agonist, is a prokinetic agent but its use has been little investigated in children. This randomized double-blind study compared the effects of premedication with oral metoclopramide 0.15 mg kg–1 or erythromycin 1 mg kg–1 on gastric emptying in 80 children undergoing tonsillectomy. Pre-operative fluids, premedication and anaesthetic technique were standardized and gastric volume was measured with an orogastric tube. Post-operative nausea and vomiting was recorded. Metoclopramide and erythromycin produced similar gastric volumes (0.29 and 0.24 ml kg–1) and there was no difference in post-operative vomiting. In the erythromycin group there were more patients with negative aspirates (45.9%) than in the metoclopramide group (35.1%), but the difference was not statistically significant. These results indicate that erythromycin may be as effective as metoclopramide as a prokinetic agent.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/86.6.869</identifier><identifier>PMID: 11573597</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Oral ; Adolescent ; anaesthesia, paediatric ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antiemetics - administration & dosage ; Biological and medical sciences ; Child ; Child, Preschool ; Double-Blind Method ; Erythromycin - administration & dosage ; Female ; Gastric Emptying - drug effects ; Gastrointestinal Agents - administration & dosage ; gastrointestinal tract, fluid volume ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Humans ; lung, aspiration ; Male ; Medical sciences ; metabolism, pre-operative fasting ; Metoclopramide - administration & dosage ; Nausea ; Postoperative Complications ; Premedication ; premedication, erythromycin ; premedication, metoclopramide ; Tonsillectomy ; Vomiting</subject><ispartof>British journal of anaesthesia : BJA, 2001-06, Vol.86 (6), p.869-871</ispartof><rights>2001 British Journal of Anaesthesia</rights><rights>2001</rights><rights>2001 INIST-CNRS</rights><rights>Copyright British Medical Association Jun 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-52f6aa2d07acb7abb61772a36371936d8ca089c7b535d599bd3d2b7cc13474bc3</citedby><cites>FETCH-LOGICAL-c460t-52f6aa2d07acb7abb61772a36371936d8ca089c7b535d599bd3d2b7cc13474bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1002646$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11573597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zatman, T.F.</creatorcontrib><creatorcontrib>Hall, J.E.</creatorcontrib><creatorcontrib>Harmer, M.</creatorcontrib><title>Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents</title><title>British journal of anaesthesia : BJA</title><addtitle>Br. J. Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>Metoclopramide may be used to stimulate gastric emptying when anaesthetizing children for emergency operations. Unfortunately, metoclopramide is associated with extrapyramidal side effects. Erythromycin, a motilin receptor agonist, is a prokinetic agent but its use has been little investigated in children. This randomized double-blind study compared the effects of premedication with oral metoclopramide 0.15 mg kg–1 or erythromycin 1 mg kg–1 on gastric emptying in 80 children undergoing tonsillectomy. Pre-operative fluids, premedication and anaesthetic technique were standardized and gastric volume was measured with an orogastric tube. Post-operative nausea and vomiting was recorded. Metoclopramide and erythromycin produced similar gastric volumes (0.29 and 0.24 ml kg–1) and there was no difference in post-operative vomiting. In the erythromycin group there were more patients with negative aspirates (45.9%) than in the metoclopramide group (35.1%), but the difference was not statistically significant. These results indicate that erythromycin may be as effective as metoclopramide as a prokinetic agent.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>anaesthesia, paediatric</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antiemetics - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Double-Blind Method</subject><subject>Erythromycin - administration & dosage</subject><subject>Female</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastrointestinal Agents - administration & dosage</subject><subject>gastrointestinal tract, fluid volume</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Humans</subject><subject>lung, aspiration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metabolism, pre-operative fasting</subject><subject>Metoclopramide - administration & dosage</subject><subject>Nausea</subject><subject>Postoperative Complications</subject><subject>Premedication</subject><subject>premedication, erythromycin</subject><subject>premedication, metoclopramide</subject><subject>Tonsillectomy</subject><subject>Vomiting</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2LFDEQxYMo7rh68yxBRC_2bNIfScebLLoKC170HKqT6t2M3UmbpBf6vzfuDCgieKm6_N6rRz1CnnO250w1F8MBLnqxF_teqAdkx1vJKyElf0h2jDFZMcXrM_IkpQNjXNaqe0zOOO9k0ym5I9sVpBydoRGTsytM9C5M64zUeWpu3WQj-ncUaMqr3agJ8wLR-RuK4-iMQ282GkaKccu3McybKTLwls6Yg5nCEmF2FikkusTw3XnM5RTcoM_pKXk0wpTw2Wmfk28fP3y9_FRdf7n6fPn-ujKtYLnq6lEA1JZJMIOEYRBcyhoa0UiuGmF7A6xXRg5d09lOqcE2th6kMbxpZTuY5py8PvqWBD9WTFnPLhmcJvAY1qQl56pTrSjgy7_AQ1ijL9k0V1IK1QteoLdHyMSQUsRRL9HNEDfNmf7Vhy596F5oUYYq-IuT5zrMaH_DpwIK8OoEQDIwjRG8cekPU1aL-2xvjlhYl_9dFEcSy0_vHEad7ntC6yKarG1w_xb-BIdntC0</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Zatman, T.F.</creator><creator>Hall, J.E.</creator><creator>Harmer, M.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents</title><author>Zatman, T.F. ; Hall, J.E. ; Harmer, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-52f6aa2d07acb7abb61772a36371936d8ca089c7b535d599bd3d2b7cc13474bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>anaesthesia, paediatric</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antiemetics - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Double-Blind Method</topic><topic>Erythromycin - administration & dosage</topic><topic>Female</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastrointestinal Agents - administration & dosage</topic><topic>gastrointestinal tract, fluid volume</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Humans</topic><topic>lung, aspiration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolism, pre-operative fasting</topic><topic>Metoclopramide - administration & dosage</topic><topic>Nausea</topic><topic>Postoperative Complications</topic><topic>Premedication</topic><topic>premedication, erythromycin</topic><topic>premedication, metoclopramide</topic><topic>Tonsillectomy</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zatman, T.F.</creatorcontrib><creatorcontrib>Hall, J.E.</creatorcontrib><creatorcontrib>Harmer, M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zatman, T.F.</au><au>Hall, J.E.</au><au>Harmer, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br. J. Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>86</volume><issue>6</issue><spage>869</spage><epage>871</epage><pages>869-871</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Metoclopramide may be used to stimulate gastric emptying when anaesthetizing children for emergency operations. Unfortunately, metoclopramide is associated with extrapyramidal side effects. Erythromycin, a motilin receptor agonist, is a prokinetic agent but its use has been little investigated in children. This randomized double-blind study compared the effects of premedication with oral metoclopramide 0.15 mg kg–1 or erythromycin 1 mg kg–1 on gastric emptying in 80 children undergoing tonsillectomy. Pre-operative fluids, premedication and anaesthetic technique were standardized and gastric volume was measured with an orogastric tube. Post-operative nausea and vomiting was recorded. Metoclopramide and erythromycin produced similar gastric volumes (0.29 and 0.24 ml kg–1) and there was no difference in post-operative vomiting. In the erythromycin group there were more patients with negative aspirates (45.9%) than in the metoclopramide group (35.1%), but the difference was not statistically significant. These results indicate that erythromycin may be as effective as metoclopramide as a prokinetic agent.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11573597</pmid><doi>10.1093/bja/86.6.869</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Adolescent anaesthesia, paediatric Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antiemetics - administration & dosage Biological and medical sciences Child Child, Preschool Double-Blind Method Erythromycin - administration & dosage Female Gastric Emptying - drug effects Gastrointestinal Agents - administration & dosage gastrointestinal tract, fluid volume General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Humans lung, aspiration Male Medical sciences metabolism, pre-operative fasting Metoclopramide - administration & dosage Nausea Postoperative Complications Premedication premedication, erythromycin premedication, metoclopramide Tonsillectomy Vomiting |
| title | Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents |
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