Apolipoprotein E genotype, coagulation, and survival following acute stroke
The authors hypothesized that divergent influences of the APOE epsilon4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-...
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| Veröffentlicht in: | Neurology 2001-09, Vol.57 (6), p.1097-1100 |
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| container_title | Neurology |
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| creator | WEIR, C. J MCCARRON, M. O MUIR, K. W DYKER, A. G BONE, I LEES, K. R NICOLL, J. A. R |
| description | The authors hypothesized that divergent influences of the APOE epsilon4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-epsilon4 carriers. Among 529 ischemic stroke patients, increasing epsilon4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients. |
| doi_str_mv | 10.1212/WNL.57.6.1097 |
| format | Article |
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Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.57.6.1097</identifier><identifier>PMID: 11571342</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Alleles ; Apolipoprotein E4 ; Apolipoproteins E - genetics ; Biological and medical sciences ; Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - genetics ; Cerebral Hemorrhage - mortality ; Cerebral Infarction - blood ; Cerebral Infarction - genetics ; Cerebral Infarction - mortality ; Follow-Up Studies ; Genetic Carrier Screening ; Genotype ; Humans ; International Normalized Ratio ; Medical sciences ; Neurology ; Partial Thromboplastin Time ; Survival Rate ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neurology, 2001-09, Vol.57 (6), p.1097-1100</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-b9d007ce8379294aa29046c36458ab881e7c24efa7d2473040c1b90536bd91f23</citedby><cites>FETCH-LOGICAL-c319t-b9d007ce8379294aa29046c36458ab881e7c24efa7d2473040c1b90536bd91f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14073423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11571342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEIR, C. J</creatorcontrib><creatorcontrib>MCCARRON, M. O</creatorcontrib><creatorcontrib>MUIR, K. W</creatorcontrib><creatorcontrib>DYKER, A. G</creatorcontrib><creatorcontrib>BONE, I</creatorcontrib><creatorcontrib>LEES, K. R</creatorcontrib><creatorcontrib>NICOLL, J. A. R</creatorcontrib><title>Apolipoprotein E genotype, coagulation, and survival following acute stroke</title><title>Neurology</title><addtitle>Neurology</addtitle><description>The authors hypothesized that divergent influences of the APOE epsilon4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-epsilon4 carriers. Among 529 ischemic stroke patients, increasing epsilon4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients.</description><subject>Alleles</subject><subject>Apolipoprotein E4</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Cerebral Hemorrhage - blood</subject><subject>Cerebral Hemorrhage - genetics</subject><subject>Cerebral Hemorrhage - mortality</subject><subject>Cerebral Infarction - blood</subject><subject>Cerebral Infarction - genetics</subject><subject>Cerebral Infarction - mortality</subject><subject>Follow-Up Studies</subject><subject>Genetic Carrier Screening</subject><subject>Genotype</subject><subject>Humans</subject><subject>International Normalized Ratio</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Partial Thromboplastin Time</subject><subject>Survival Rate</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1PwzAQgGELgWgpjKwoC0xN8Fdie6yq8iEqWECwWY7jVAY3DnZS1H9PqlbqdMM9Op1eAK4RzBBG-P7zdZnlLCsyBAU7AWOU4yItCP46BWMIMU8JZ3wELmL8hnBYMnEORgjlDBGKx-Bl1npnW98G3xnbJItkZRrfbVszTbRXq96pzvpmmqimSmIfNnajXFJ75_yfbVaJ0n1nktgF_2MuwVmtXDRXhzkBHw-L9_lTunx7fJ7PlqkmSHRpKSoImTacMIEFVQoLSAtNCppzVXKODNOYmlqxClNGIIUalQLmpCgrgWpMJuBuf3d4-rc3sZNrG7VxTjXG91EyhEQuEB9guoc6-BiDqWUb7FqFrURQ7urJoZ7MmSzkrt7gbw6H-3JtqqM-5BrA7QGoqJWrg2q0jUdHIdsx8g8dW3cU</recordid><startdate>20010925</startdate><enddate>20010925</enddate><creator>WEIR, C. 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J</creatorcontrib><creatorcontrib>MCCARRON, M. O</creatorcontrib><creatorcontrib>MUIR, K. W</creatorcontrib><creatorcontrib>DYKER, A. G</creatorcontrib><creatorcontrib>BONE, I</creatorcontrib><creatorcontrib>LEES, K. R</creatorcontrib><creatorcontrib>NICOLL, J. A. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEIR, C. J</au><au>MCCARRON, M. O</au><au>MUIR, K. W</au><au>DYKER, A. G</au><au>BONE, I</au><au>LEES, K. R</au><au>NICOLL, J. A. 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Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11571342</pmid><doi>10.1212/WNL.57.6.1097</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neurology, 2001-09, Vol.57 (6), p.1097-1100 |
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| subjects | Alleles Apolipoprotein E4 Apolipoproteins E - genetics Biological and medical sciences Cerebral Hemorrhage - blood Cerebral Hemorrhage - genetics Cerebral Hemorrhage - mortality Cerebral Infarction - blood Cerebral Infarction - genetics Cerebral Infarction - mortality Follow-Up Studies Genetic Carrier Screening Genotype Humans International Normalized Ratio Medical sciences Neurology Partial Thromboplastin Time Survival Rate Vascular diseases and vascular malformations of the nervous system |
| title | Apolipoprotein E genotype, coagulation, and survival following acute stroke |
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